Academia

Publications

Contributing to the scientific community

Dr. Dennis Liotta has authored over 300 research papers, scientific commentaries, and book chapters. The sections below list Dr. Liotta’s most impactful publications as well as his most cited publications.

  1. The synthesis, anti-HIV and anti-HBV activity of pyrimidine oxathiolane nucleoside analogues, Bioorg. Med. Chem. Lett., 1993, 3(4), 693-6
  2. The anti-hepatitis B virus activity, cytotoxicity and anabolic profile of the (-) and (+) enantiomers of cis-5-fluoro-1-{2-hydroxymethyl)-1,3-oxythiolane-5-yl} cytosine (FTC), Antimicrob. Agents Chemother., 1992, 36(12), 2686-92
  3. Enzyme-mediated enantioselective preparation of pure enantiomers of the antiviral agent FTC and related compounds, J. Bio. Chem., 1992, 57(21), 5563-5
  4. In Situ complexation directs the stereochemistry of N-glycosylation in the synthesis of thialanyl and dioxolanyl nucleoside analogues, J. Am. Chem. Soc., 1991, 113(24), 9377-9
    1. A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2 and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration, J. Med. Chem.,2010,53(24), 8508-22
    1. Development of a unique small molecule modulator of CXCR4, PLoS One, 2012, 7(4), e34038
    2. Discovery of small molecule CXCR4 antagonists, J. Med. Chem., 2007, 50(23), 5655-64
      1. A GluN2B-selective inhibitor of NMDA receptor function with enhanced potency at acidic pH and oral bioavailability for clinical use, J. Pharmacol. Exp. Ther., 2021, 379(1), 41-52
      1. Development of a novel progesterone analog in the treatment of traumatic brain injury, Neuropharmacology, 2019, 145, 292-8
      2. Evaluating the neurotherapeutic potential of a water-soluble progesterone analog after traumatic brain injury in rats, Neuropharmacology, 2016, 109, 148-58

        11. Design and optimization of novel competitive, non-peptidic, SARS-CoV-2 Mpro inhibitors, ACS Med. Chem. Lett., 2023, 14(10), 1434-40

        1. Design and optimization of novel competitive, non-peptidic, SARS-CoV-2 Mpro inhibitors, ACS Med. Chem. Lett., 2023, 14(10), 1434-40
        2. Discovery of 5′-substituted 5-fluoro-2′-deoxyuridine monophosphate analogs: a novel class of thymidylate synthase inhibitors, ACS Pharmacol. Transl. Sci., 2023, 6(5), 702-9
        3. Neurotherapeutic potential of water-soluble pH-responsive prodrugs of EIDD-036 in traumatic brain injury, J. Med. Chem., 2023, 66(8), 5397-414
        4. ω-Functionalized lipid prodrugs of HIV NtRTI tenofovir with enhanced pharmacokinetic properties, J. Med. Chem., 2021, 64(17), 12917-37
        5. Biased modulators of NMDA receptors control channel opening and ion selectivity, Nat. Chem. Biol., 2020, 6(2), 188-96
        6. Accelerated discovery of novel ponatinib analogs with improved properties for the treatment of Parkinson’s disease, ACS Med. Chem. Lett., 2020, 11(4), 491-6
        7. Design, synthesis, and pharmacological evaluation of second-generation tetrahydroisoquinoline-based CXCR4 antagonists with favorable ADME properties, J. Med. Chem., 2018, 61(16), 7168-88

          Selected publications with the most citations

          1. Inhibition of the replication of hepatitis B virus in vitro by 2’,3′-dideoxy-3′-thiacytidine and related analogues, Proc. Natl. Acad. Sci. U.S.A., 1991, 88, 8495-9
          2. Synthesis and biological evaluation of novel curcumin analogs as anti-cancer and anti-angiogenesis agents, Bioorg. Med. Chem., 2004, 12, 3871-83
          3. Biodiversity of sphingoid bases (“sphingosines”) and related amino alcohols, J. Lipid Res., 2008, 49, 1621-39
          4. Polyoxometalate HIV-1 protease inhibitors – a new mode of protease inhibition, J. Am. Chem. Soc., 2001, 123, 886-97
          5. Selectivity of ceramide-mediated biology – lack of activity of erythro-dihydroceramide, J. Bio. Chem., 1993, 268, 26226-32
          6. Quantitation of free sphingosine in liver by high-performance liquid chromatography, Anal. Chem., 1988, 171, 373-81
          7. The anti-hepatitis B virus activities, cytotoxicities, and anabolic profiles of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine, Antimicrob. Agents Chemother., 1992, 36, 2686-92
          8. EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism, Anti-Cancer Drugs, 2005, 16, 263-75
          9. New organoselenium methodology, Acc. Chem. Res., 1984, 17, 28-34

          Complete publication list

          1. Jecs E., Tahirovic Y.A., Wilson R.J., Miller E.J., Kim M., Truax V., Nguyen H.H., Akins N.S., Saindane M., Wang T., Sum C.S., Cvijic M.E., Schroeder G.M., Burton S.L., Derdeyn C.A., Xu L., Jiang Y., Wilson L.J., Liotta D.C. Synthesis and Evaluation of Novel Tetrahydronaphthyridine CXCR4 Antagonists with Improved Drug-like Profiles. J. Med. Chem. 2022,65 (5), 4058-4084. PMID: 35179893. DOI: 10.1021/acs.jmedchem.1c01564.
          2. Nguyen H.H.; Tahirovic Y.A.; Truax V.M.; Wilson R.J.; Jecs E.; Miller E.J.; Kim M.B.; Akins N.S.; Xu L.; Jiang Y.; Wang T.; Sum C.S.; Cvijic M.E.; Schroeder G.M.; Wilson L.J.; Liotta D.C. Amino-Heterocycle Tetrahydroisoquinoline CXCR4 Antagonists with Improved ADME Profiles via Late-Stage Buchwald Couplings. ACS Med. Chem. Lett. 2021,12 (10), 1605-1612. PMID: 34676043. PMCID: PMC8521655. DOI: 10.1021/acsmedchemlett.1c00449.
          3. Myers S.J.; Ruppa K.P.; Wilson L.J.; Tahirovic Y.A.; Lyuboslavsky P.; Menaldino D.S.; Dentmon Z.W.; Koszalka G.W.; Zaczek R.; Dingledine R.J.; Traynelis S.F.; Liotta D.C. A Glutamate N-Methyl-d-Aspartate (NMDA) Receptor Subunit 2B-Selective Inhibitor of NMDA Receptor Function with Enhanced Potency at Acidic pH and Oral Bioavailability for Clinical Use. J. Pharmacol. Exp. Ther. 2021,379 (1), 41-52. PMID: 34493631. DOI: 10.1124/jpet.120.000370.
          4. Pribut N.; D’Erasmo M.; Dasari M.; Giesler K.E.; Iskandar S.; Sharma S.K.; Bartsch P.W.; Raghuram K.; Bushnev A; Hwang S.S.; Burton S.L.; Derdeyn C.A.; Basson A.E.; Liotta D.C.; Miller E.J. ω-Functionalized Lipid Prodrugs of HIV NtRTI Tenofovir with Enhanced Pharmacokinetic Properties. J. Med. Chem. 2021,64 (17), 12917-12937. PMID: 34459598. DOI: 10.1021/acs.jmedchem.1c01083.
          5. Perszyk, R.E.; Zheng, Z.; Banke, T.G.; Zhang, J.; Xie, L.; McDaniel, M.J.; Katzman,
            B.M.; Pelly, S.C.; Yuan, H.; Liotta, D.C.; Traynelis, S.F. The Negative Allosteric
            Stanford University AbbVie Modulator EU1794-4 Reduces Single-Channel Conductance and Ca 2+ Permeability of GluN1/GluN2A N-Methyl-d-Aspartate Receptors. Mol. Pharmacol. 2021, 99 (5), 399- 411. PMID: 33688039. PMCID: PMC8058507 (available on 2022-05-01). DOI: 10.1124/molpharm.120.000218.
          6. Pelly, S.; Liotta, D. Potent SARS-CoV-2 Direct-Acting Antivirals Provide an Important Complement to COVID-19 Vaccines. ACS Cent. Sci. 2021, 7 (3), 396-399. PMID: 33786374. PMCID: PMC7945585. DOI: 10.1021/acscentsci.1c00258.
          7. Strong, K.L.; Epplin, M.W.; Ogden, K.K.; Burger, P.B.; Kaiser, T.M.; Wilding, T.J.; Kusumoto, H.; Camp, C.R.; Shaulsky, G; Bhattacharya, S.; Perszyk, R.E.; Menaldino, D.S.; McDaniel, M.J.; Zhang, J.; Le, P.; Banke, T.G.; Hansen, K.B.; Huettner, J.E.; Liotta, D.C.; Traynelis, S.F. Distinct GluN1 and GluN2 Structural Determinants for Subunit-Selective Positive Allosteric Modulation of N-Methyl-d-aspartate Receptors. ACS Chem. Neurosci. 2021, 12 (1),79-98. PMID: 33326224. PMCID: PMC7967294 (available on 2022-01-06). DOI: 10.1021/acschemneuro.0c00561.
          8. Dasari, M.; Ma, P.; Pelly, S.C.; Sharma, S.K.; Liotta, D.C. Synthesis and Biological Evaluation of 5′-C-Methyl Nucleotide Prodrugs for Treating HCV Infections. Bioorg. Med. Chem. Lett. 2020, 30 (23),127539. PMID: 32919013. DOI: 10.1016/j.bmcl.2020.127539.
          9. Dentmon, Z.W.; Kaiser, T.M.; Liotta, D.C. Synthesis and Antiviral Activity of a Series of 2′- C-Methyl-4′-thionucleoside Monophosphate Prodrugs. Molecules. 2020, 25 (21), 5165. PMID: 33171951 PMCID: PMC7664256. DOI: 10.3390/molecules25215165.
          10. Zhu Z.; Yi , F.; Epplin, M.P.; Liu, D.; Summer, S.L.; Mizu, R.; Shaulsky, G.; XiangWei, W.; Tang,W.; Burger, P.B.; Menaldino, D.S.; Myers, S.J.; Liotta, D.C.; Hansen, K.B.; Yuan, H; Traynelis, S.F. Negative Allosteric Modulation of GluN1/GluN3 NMDA Receptors. Neuropharm. 2020, 176, 108117.
          11. Zhu Z.; Yi , F.; Epplin, M.P.; Liu, D.; Summer, S.L.; Mizu, R.; Shaulsky, G.; XiangWei, W.; Tang,W.; Burger, P.B.; Menaldino, D.S.; Myers, S.J.; Liotta, D.C.; Hansen, K.B.; Yuan, H; Traynelis, S.F. Negative Allosteric Modulation of GluN1/GluN3 NMDA Receptors. Neuropharm. 2020, 11 (4), 491-496.
          12. Kaiser, T.M.; Dentmon, Z.W.; Dalloul, C.E.; Sharma, S.K.; Liotta, D.C. Accelerated Discovery of Novel Ponatinib Analogs with Improved Properties for the Treatment of Parkinson’s Disease. ACS Med. Chem. Lett. 2020, 11(4), 491-496.
          13. Epplin, M.; Mohan, A.; Harris, L.; Zhu, Z.; Bacsa, J.; Menaldino, D.; Traynelis, S.; Liotta, D.  ; Le, P. Discovery of Dihydropyrrolo[1,2-a]pyrazin-3(4H)-one-based Second-Generation GluN2C- and GluN2D-Selective Positive Allosteric Modulators (PAMs) of the N-methyl-D-aspartate (NMDA) Receptor. J. Med. Chem. 2020. (Submitted).
          14. Pribut, N.; Kaiser, T.M.; Wilson, R.J.; Jecs, E.; Dentmon, Z.W.; Pelly, S.; Sharma, S.K.; Bartsch, P.; Burger, P.B.; Hwang, S.; Le, T.; Sourimant, J.; Yoon, J.J.; Plemper, R.K.; Liotta, D.C. Accelerated Discovery of Potent Fusion Inhibitors for Respiratory Syncytial Virus. ACS Infect. Dis. 2020. [Epub ahead of print]
          15. McDaniel, M.J.; Ogden, K.K.; Kell, S.A.; Burger, P.B.; Liotta, D.C.; Traynelis, S.F. NMDA Receptor Channel Gating Control by the Pre-M1 Helix. J. Gen. Physiol. 2020 152 (4), e201912362.
          16. Perszyk, R.E.; Swanger, S.A.; Shelley, C.; Khatri, A.; Fernandez-Cuervo, G.; Epplin, M.P.; Zhang, J.; Le, P.; Bülow, P.; Garnier-Amblard, E.; Gangireddy, P.K.R.; Bassell, G.J.; Yuan, H.; Menaldino, D.S.; Liotta, D.C.; Liebeskind, L.S.; Traynelis, S.F. Biased Modulation of a Ligand-Gated Ion Channel. Nat. Chem. Bio. 2019, (Submitted).
          17. Nijampatnam, B.; Liotta, D. Recent Advances in the Development of HBV Capsid Assembly Modulators. Curr. Opin. in Chem. Biol. 2019, 50, 73-79.
          18. Pribut, N.; Basson, A.E.; van Otterlo, W.A.L.; Liotta, D.C.; Pelly, S.C. Aryl Substituted Benzimidazolones as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors. ACS Med. Chem. Lett. 2019, 10 (2), 196-202.
          19. Katzman, B.; Cox, B.; Prosser, A.; Alcaraz, A.; Murat, B.; Heroux, M.; Tebben, A.; Zhang, Y.; Schroeder, G.; Snyder, J.; Liotta, D.C.; Wilson, L. Tetrahydroisoquinoline CXCR4 Antagonists Adopt a Hybrid Binding Mode within the Peptide Subpocket of the CXCR4 Receptor. ACS Med. Chem. Lett. 2019, 10 (1), 67-73.
          20. Summer, S.L.; Kell, S.A.; Zhu, Z.; Moore, R.; Liotta, D.C.; Myers, S.J.; Koszalka, G.W.; Traynelis, S.F.; Menaldino, D. S. Di-aryl Sulfonamide Motif Adds π-Stacking Bulk in Negative Allosteric Modulators of the NMDA Receptor. ACS Med. Chem. Lett. 2019, 10 (3), 248-254.
          21. Regan, M.C.; Zhu, Z.; Yuan, H.; Myers, S.J.; Menaldino, D.; Altas Tahirovic, Y.; Liotta, D.; Traynelis, S.F.; Furukawa, H. Structural Elements of a pH-Sensitive Inhibitor Binding Site in NMDA Receptors. Nature Commun. 2019, 10:321.
          22. Shoji, M.; Qian, W.P.; Nagaraju, G.P.; Brat, D.J.; Pessolano, D.; Luzietti, R.; Chennamadhavuni, S.; Yamaguchi, M.; Yang, L.; Liotta, D.C. Inhibition of Breast Cancer Metastasis to the Lung with UBS109. Oncotarget. 2018, 9 (90), 36102–36109.
          23. Wells, G.; Yuan, H.; McDaniel, M.J.; Kusumoto, H.; Snyder, J.P.; Liotta, D.C.; Traynelis, S.F. The GluN2B-Glu413Gly NMDA Receptor Variant Arising from a de novo GRIN2B Mutation Promotes Ligand-Unbinding and Domain Opening. Proteins. 2018, 2018, 86 (12), 1265-1276.
          24. Sayeed, I.; Wali, B.; Guthrie, D.B.; Saindane, M.T.; Natchus, M.G.; Liotta, D.C.; Stein, D.G. Development of a Novel Progesterone Analog in the Treatment of Traumatic Brain Injury. Neuropharmacol. 2019, 145 (Pt B), 292-298.
          25. Shoji, M.; Adams, B.K.; Ferstl, E.M.; Sunay, U.B.; Hollingshead, M.G.; Sausville, E.A.; Reid, J.M.; Zhu, S.; Yamaguchi, M.; Nagaraju, G.P.; Balney, R.; Chenna Madhavuni, S.; Qian, W.P.; Yang, L.; Pessolano, D.; Luzietti, R.; Sun, A.; Snyder, J.P.; El-Rayes, B.F.; Meisel, J.L.; Brat, D.J.; Liotta, D.C. Inhibition of Breast Cancer Bone Metastasis and Pancreatic and Colon Cancer by Synthetic Curcumin Analogs. Cancer Prog. Diagn. 2018, 2 (1), 58-64.
          26. Gibb, A.J.; Ogden, K.K.; McDaniel, M.J.; Vance, K.M.; Kell, S.A.; Butch, C.; Burger, P.; Liotta, D.C.; Traynelis, S.F. A structurally-derived model of subunit-dependent NMDA receptor function. J. Physiol. 2018, 596 (17), 4057-4098.
          27. Nguyen, H.H.; Kim, M.B.; Wilson, R.J.; Butch, C.J.; Kuo, K.M.; Miller, E.J.; Altas Tahirovic, Y.; Jecs, E.; Truax, V.M.; Wang, T.; Sum, C.S.; Cvijic, M.E.; Schroeder, G.M.; Wilson, L.J.; Liotta, D.C. Design, Synthesis, and Pharmacological Evaluation of Second-Generation Tetrahydroisoquinoline-Based CXCR4 Antagonists with Favorable ADME Properties. J. Med. Chem. 2018, 61 (16), 7168-7188.
          28. Perszyk, R.E.; Katzman, B.M.; Kusumoto, H.; Kell, S.A.; Epplin, M.P.; Altas Tahirovic, Y.; Moore, R.L.; Menaldino, D.; Burger, P.; Liotta, D.C.; Traynelis, S.F. An NMDAR Positive and Negative Allosteric Modulator Series Share a Binding Site and are Interconverted by Methyl Groups. eLife. 2018, 7, e34711.
          29. Liotta, D.; Painter, G. Academic Drug Development: The DRIVE Model. ACS Med Chem. Lett. 2018, 9 (5), 403-407.
          30. Kaiser, T.M.; Burger, P.B.; Butch, C.J.; Pelly, S.C.; Liotta, D.C. A Machine Learning Approach for Predicting HIV Reverse Transcriptase Mutation Susceptibility of Biologically Active Compounds, J. Chem. Inf. Model. 2018, 58 (8), 1544-1552.
          31. Huang, M.B.; Giesler, K.E.; Katzman, B.M.; Prosser, A.R.; Truax, V.; Liotta, D.C.; Wilson, L.J.; Bond, V.C. Small Molecule CXCR4 Antagonists Block the HIV-1 Nef/CXCR4 Axis and Selectively Initiate the Apoptotic Program in Breast Cancer Cells. Oncotarget. 2018, 9 (24), 16996-17013.
          32. Liotta, D.C.; Nwaka, S.; Sencer, S.D.; Vertinsky, L. North-South Collaborations to Promote Heath Innovation in Africa. Emory Law Journal. 2018, 67, 620-649.
          33. Altas Tahirovic, Y.; Truax, V.M.; Wilson, R.J.; Jecs, E.; Nguyen, H.H.; Miller, E.J.; Kim, M.B.; Kuo, K.M.; Wang, T.; Sum, C.S.; Cvijic, M.E.; Schroeder, G.M.; Wilson, L.J.; Liotta, D.C. Discovery of N-Alkyl Piperazine Side Chain Based CXCR4 Antagonists with Improved Drug-like Properties. ACS Med. Chem. Lett. 2018, 9 (5), 446-451.
          34. Wilson, R.J.; Jecs, E.; Miller, E.J.; Nguyen, H.H.; Altas Tahirovic, Y.; Truax, V.M.; Kim, M.B.; Kuo, K.M.; Wang, T.; Sum, C.S.; Cvijic, M.E.; Paiva, A.A.; Schroeder, G.M.; Wilson, L.J.; Liotta, D.C. Synthesis and SAR of 1,2,3,4-Tetrahydroisoquinoline-Based CXCR4 Antagonists. ACS Med. Chem. Lett. 2018, 9 (1), 17-22.
          35. Miller, E.J.; Jecs, E.; Truax, V.M.; Katzman, B.M.; Altas Tahirovic, Y.; Wilson, R.J.; Kuo, K.M.; Kim, M.B.; Nguyen, H.H.; Saindane, M.T.; Zhao, H.; Wang, T.; Sum, C.S.; Cvijic, M.E.; Schroeder, G.M.; Wilson, L.J.; Liotta, D.C. Discovery of Tetrahydroisoquinoline-Containing CXCR4 Antagonists with Improved In Vitro ADMET Properties. J. Med. Chem. 2018, 61 (3), 946-979.
          36. Kaiser, T.M.; Kell, S.A.; Kusumoto, H.; Shaulsky, G.; Bhattacharya, S.; Epplin, M.P.; Stong, K.L.; Miller, E.J.; Cox, B.D.; Menaldino, D.S.; Liotta, D.C.; Traynelis, S.F.; Burger, P.B. The Bioactive Protein-Ligand Conformation of GluN2C-Selective Positive Allosteric Modulators Bound to the NMDA Receptor. Mol. Pharmacol. 2018, 93 (2) 141-156.
          37. Swanger, S.A.; Vance, K.M.: Acker, T.M.; Zimmerman, S.S.; DiRaddo, J.O.; Myers, S.J.; Bundgaard, C.; Mosley, C.A.; Summer, S.L.; Menaldino, D.S.; Jensen, H.S.; Liotta, D.C.; Traynelis, S.F. A Novel Negative Allosteric Modulator Selective for GluN2C/2D-Containing NMDA Receptors Inhibits Synaptic Transmission in Hippocampal Interneurons. ACS Chem. Neurosci. 2018, 9 (2), 306-319.
          38. Jecs, E.; Miller, E.J.; Wilson, R.J.; Nguyen, H.H.; Altas Tahirovic, Y.; Katzman, B.M.; Truax, V.M.; Kim, M.B.; Kuo, K.M.; Wang, T.; Sum, C.S.; Cvijic, M.E.; Schroeder, G.M.; Wilson, L.J.; Liotta, D.C. Synthesis of Novel Tetrahydroisoquinoline CXCR4 Antagonists with Rigidified Side-Chains. ACS Med. Chem. Lett. 2018, 9 (2), 89-93.
          39. Strong, K.L.; Epplin, M.P.; Bacsa, J.; Butch, C.J.; Burger, P.B.; Menaldino, D.S.; Traynelis, S.F.; Liotta, D.C. The Structure-Activity Relationship of a Tetrahydroisoquinoline Class of N-Methyl-D-Aspartate Receptor Modulators that Potentiates GluN2B-Containing N-Methyl-d-Aspartate Receptors. J. Med. Chem. 2017, 60 (13), 5556-5585.
          40. Perszyk, R.E.; Ogden, K.K.; Strong, K.L.; Liotta, D.C.; Traynelis, S.F. Channel Open Probability Controls Allosteric Modulation of Potency and Efficacy. Biophys. J. 2017, 112 (3), 420a – 421a.
          41. Aldrich, C.; Bertozzi, C.; Georg, G.I.; Kiessling, L.; Lindsley, C.; Liotta, D.; Merz, K.M.; Schepartz, A.; Wang, S. The Ecstasy and Agony of Assay Interference Compounds. ACS Chem. Biol. 2017, 56 (10), 575-578.
          42. Jiménez-Somarribas, A.; Mao, S.; Yoon, J.J.; Weisshaar, M.; Cox, R.M.; Marengo, J.R.; Mitchell, D.G.; Morehouse, Z.P.; Yan, D.; Solis, I.; Liotta, D.C.; Natchus, M.G.; Plemper, R.K. Identification of Non-Nucleoside Inhibitors of the Respiratory Syncytial Virus Polymerase Complex. J. Med. Chem. 2017, 60 (6), 2305-2325.
          43. Perszyk, R.E.; DiRaddo, J.O.; Strong, K.L.; Low, C.M.; Ogden, K.K.; Khatri, A.; Vargish, G.A.; Pelkey, K.A.; Tricoire, L.; Liotta, D.C.; Smith, Y.; McBain, C.J.; Traynelis, S.F. GluN2D-Containing N-Methyl-D-Aspartate Receptors Mediate Synaptic Transmission in Hippocampal Interneurons and Regulate Interneuron Activity. Mol. Pharmacol. 2016, 90 (6),689-702.
          44. Kim, M.B.; Giesler, K.E.; Tahirovic, Y.A.; Truax, V.M.; Liotta, D.C.; Wilson, L.J. CCR5 Receptor Antagonists in Preclinical to Phase II Clinical Development for Treatment of HIV. Expert Opinion on Investigational Drugs. 2016, 25 (12), 1377-1392.
          45. Giesler, K.E., Liotta, D.C. Next-Generation Reduction Sensitive Lipid Conjugates of Tenofovir: Antiviral Activity and Mechanism of Release. J. Med. Chem. 2016, 59 (22), 10244-10252.
          46. Liotta, D.C.; Painter, G.R. Discovery and Development of the Anti-Human Immunodeficiency Virus Drug, Emtricitabine (Emtriva). Acc. Chem. Res. 2016, 49 (10), 2091-2098.
          47. Giesler, K.E.; Marengo, J.; Liotta, D.C. Reduction Sensitive Lipid Conjugates of Tenofovir: Synthesis, Stability, and Antiviral Activity. J. Med. Chem. 2016, 59 (15), 7097-7110 (Correction: J. Med. Chem. 2017, 60 (8), 3531–3531).
          48. Wali, B.; Sayeed, I.; Guthrie, D.B.; Natchus, M.G.; Turan, N.; Liotta, D.C.; Stein, D.G. Evaluating the Neurotherapeutic Potential of a Water-Soluble Progesterone Analog After Traumatic Brain Injury in Rats. Neuropharma. 2016, 109, 148-158.
          49. Pippin, A.B.; Mohd Arshad, Z.H.; Voll, R.J.; Nye, J.A.; Ghassabian, S.; Williams, C.M.; Mancini, A.; Liotta, D.C.; Smith, M.T.; Goodman, M.M. In Vitro Metabolic Stability and In Vivo Biodistribution of 3-Methyl-4-Furoxancarbaldehyde Using PET Imaging in Rats. ACS Med. Chem. Lett. 2016, 7 (6), 563-567.
          50. Miller, E.J.; Mays, S.G.; Baillie, M.T.; Howard, R.B.; Culver, D.G.; Saindane, M.; Pruett, S.T.; Holt, J.J.; Menaldino, D.S.; Evers, T.J.; Reddy, G.P.; Arrendale, R.F.; Natchus, M.G.; Petros, J.A.; Liotta, D.C. Discovery of a Fluorinated Enigmol Analog with Enhanced In Vivo Pharmacokinetic and Anti-Tumor Properties. ACS Med. Chem. Lett 2016, 7 (5), 537-542.
          51. Katzman, B.M.; Perszyk, R.E.; Yuan, H.; Altas Tahirovic, Y.; Sotimehin, A.E.; Traynelis, S.F.; Liotta, D.C. A Novel Class of Negative Allosteric Modulators of NMDA Receptor Function. Bioorg. Med. Chem. Lett. 2015, 25 (23), 5583-5588.
          52. Cox, B.D.; Mehta, A.K.; DiRaddo, J.O.; Liotta, D.C.; Wilson, L.J.; Snyder, J.P. Structural analysis of CXCR4 –Antagonist interactions using saturation-transfer double-difference NMR. Biochem. Biophys. Res. Commun. 2015, 466 (1), 28-32.
          53. DiRaddo, J.O.; Miller, E.J.; Bowman-Dalley, C.; Wroblewska, B.; Javidnia, M.; Grajkowska, E.; Wolfe, B.B.; Liotta, D.C.; Wroblewski, J.T. Chloride is an Agonist of Group II and III Metabotropic Glutamate Receptors. Mol. Pharmacol. 2015, 88 (3), 450-459.
          54. Cox, B.D.; Prosser, A.R.; Sun, Y.; Li, Z.; Lee, S.; Huang, M.B.; Bond, V.C.; Snyder, J.P.; Krystal, M.; Wilson, L.J.; Liotta, D.C. Pyrazolo-Piperidines Exhibit Dual Inhibition of CCR5/CXCR4 HIV Entry and Reverse Transcriptase. ACS Med. Chem. Lett. 2015, 6 (7), 753-757.
          55. Zhao, H.; Prosser, A.R.; Liotta, D.C.; Wilson, L.J. Discovery of Novel N-Aryl Piperazine CXCR4 Antagonists. Bioorg. & Med. Chem. Lett. 2015, 25 (21), 4950-4955.
          56. Yuan, H.; Myers, S.J.; Wells, G.; Nicholson, K.L.; Swanger, S.A.; Lyuboslavsky, P.; Tahirovic, Y.A.; Menaldino, D.S.; Ganesh, T.; Wilson, L.J.; Liotta, D.C.; Snyder, J.P.; Traynelis, S.F. Context-Dependent GluN2B-Selective Inhibitors of NMDA Receptor Function Are Neuroprotective with Minimal Side Effects. Neuron. 2015, 85 (6), 1305-1318.
          57. Baldwin, P.R.; Reeves, A.Z.; Powell, K.R.; Napier, R.J.; Swimm, A.I.; Sun, A.; Giesler, K.; Bommarius, B.; Shinnick, T.M.; Snyder, J.P.; Liotta, D.C.; Kalman, D. Monocarbonyl analogs of curcumin inhibit growth of antibiotic sensitive and resistant strains of Mycobacterium tuberculosis. Eur. J. Med. Chem. 2015, 92 (6), 693-699.
          58. Khatri, A.; Burger, P.B.; Swanger, S.A.; Hansen, K.B.; Zimmerman, S.; Karakas, E.; Liotta, D.C.; Furukawa, H.; Snyder, J.P.; Traynelis, S.F. Structural Determinants and Mechanism of Action of GluN2C-Selective NMDA Receptor Positive Allosteric Modulator. Mol. Pharmacol. 2014, 86 (5), 548–560.
          59. Zhu, S.; Kisiel, W.; Lu, Y.J.; Petersen, L.C.; Ndungu, J.M.; Moore, T.W.; Parker, E.T.; Sun, A.; Liotta, D.C.; El-Rayes, B.F.; Brat, D.J.; Snyder, J.P.; Shoji, M. Tumor Angiogenesis Therapy Using Targeted Delivery of Paclitaxel to the Vasculature of Breast Cancer Metastases. J. Drug Deliv. 2014, ID 865732.
          60. Zhu, S.; Kisiel, W.; Lu, Y.J.; Petersen, L.C.; Ndungu, J.M.; Moore, T.W.; Parker, E.T.; Sun, A.; Sarkaria, J.N.; Snyder, J.P.; Liotta, D.C.; Brat, D.J.; El-Rayes, B.; Shoji, M. Visualizing Cancer and Response to Therapy In Vivo Using Cy5.5-Labeled Factor VIIa and Anti-Tissue Factor Antibody. J. Drug Target. 2015, 23 (3), 257-265.
          61. Strong, K.L.; Jing, Y.; Prosser, A.R.; Traynelis, S.F.; Liotta, D.C. NMDA Receptor Modulators: An Updated Patent Review (2013-2014). Expert Opin. Ther. Patents. 2014, 24 (12), 1349-1366.
          62. Zhou, T.; Ye, L.; Bai, Y.; Sun, A.; Cox, B.; Liu, D.; Li, Y.; Liotta, D.; Snyder, J.P.; Fu, H.; Huang, B. Autophagy and Apoptosis in Hepatocellular Carcinoma Induced by EF25-(GSH)2: A Novel Curcumin Analog. PLoS One. 2014, 9 (9), e107876.
          63. DiRaddo, J.O.; Miller, E.J.; Hathaway, H.A.; Grajkowska, E.; Wroblewska, B.; Wolfe, B.B.; Liotta, D.C.; Wroblewski, J.T. A Real-Time Method for Measuring cAMP Production Modulated by Gαi/o-Coupled Metabotropic Glutamate Receptors. J. Pharmacol. Exp. Ther. 2014, 349 (3), 373–382.
          64. Hu, H.; Mao, S.; Bugrysheva, J.V.; Pruett, S.; Liotta, D.C.; Scott, J.R.; Snyder, J.P. Group A Streptococcus Inhibitors by High-Throughput Virtual Screening. Eur. J. Med. Chem. 2014, 82, 120-126.
          65. Cox, B.D.; Prosser, A.R.; Katzman, B.M.; Alcaraz, A.A.; Liotta, D.C.; Wilson, L.J.; Snyder, J.P. Anti-HIV Small-Molecule Binding in the Peptide Subpocket of the CXCR4:CVX15 Crystal Structure. Chem. BioChem. 2014, 15 (11), 1614-1620.
          66. Krumm, S.A.; Yan, D.; Hovingh, E.S.; Evers, T.J.; Enkirch, T.; Reddy, G.P.; Sun, A.; Saindane, M.T.; Arrendale, R.F.; Painter, G.; Liotta, D.C.; Natchus, M.G.; von Messling, V.; Plemper, R.K. Orally Available, Small-Molecule Polymerase Inhibitor Cures a Lethal Morbillivirus Infection. Sci. Transl. Med. 2014, 6 (232), 232ra52.
          67. Zimmerman, S.S.; Khatri, A.; Garnier-Amblard, E.C.; Mullasseril, P.; Kurtkaya, N.L.; Gyoneva, S.; Hansen, K.B.; Traynelis, S.F.; Liotta, D.C. Design, Synthesis, and Structure–Activity Relationship of a Novel Series of GluN2C-Selective Potentiators. J. Med. Chem. 2014, 57 (6), 2334-2356 (Correction: J. Med. Chem. 2015, 58 (6), 2862).
          68. Prosser, A.R.; Liotta, D.C. One-Pot Transformation of Esters to Analytically Pure Ketones: Methodology and Application in Process Development. Tetrahedron Lett. 2014. 56 (23), 3005-3007.
          69. Truax, V.M.; Zhao, H.; Katzman, B.M.; Prosser, A.R.; Alcaraz, A.A.; Saindane, M.T.; Howard, R.B.; Culver, D.; Arrendale, R.F.; Gruddanti, P.R.; Taylor, J.E.; Natchus, M.G.; Snyder, J.P.; Liotta, D.C.; Wilson, L.J. Discovery of Tetrahydroisoquinoline-Based CXCR4 Antagonists. ACS Med. Chem. Lett. 2013, 4 (11), 1025-1030.
          70. Acker, T.M.; Khatri, A.; Vance, K.M.; Slabber, C.; Bacsa, J.; Snyder, J.P.; Traynelis, S.F.; Liotta, D.C. Structure-Activity Relationships and Pharmacophore Model of a Noncompetitive Pyrazoline containing Class of GluN2C/GluN2D Selective Antagonists. J. Med. Chem. 2013, 56 (16), 6434-6456.
          71. Moore, T.W.; Sana, K.; Yan, D.; Krumm, S.A.; Thepchatri, P.; Snyder, J.P.; Marengo, J.; Arrendale, R.F.; Prussia, A.J.; Natchus, M.G.; Liotta, D.C. Synthesis and Metabolic Studies of Host-Directed Inhibitors for Antiviral Therapy. ACS Med. Chem. Lett. 2013, 4 (8), 762-767.
          72. Santangelo Freel, R.M.; Ogden, K.K.; Strong, K.L.; Khatri, A.; Chepiga, K.M.; Jensen, H.S.; Traynelis, S.F.; Liotta, D.C. Synthesis and Structure Activity Relationship of Tetrahydroisoquinoline-Based Potentiators of GluN2C and GluN2D Containing N-Methyl-D-aspartate Receptors. J. Med. Chem. 2013, 56 (13), 5351-5381 (Correction: J. Med. Chem. 2014, 57 (11), 4975).
          73. Brown, A.; Shi, Q.; Moore, T.W.; Yoon, Y.; Prussia, A.; Maddox, C.; Liotta, D.C.; Shim, H.; Snyder, J.P. Monocarbonyl Curcumin Analogues: Heterocyclic Pleiotropic Kinase Inhibitors That Mediate Anticancer Properties. J. Med. Chem. 2013, 56 (9), 3456-3466.
          74. Moore, T.W.; Sana, K.; Yan, D.; Thepchatri, P.; Ndungu, J.M.; Sandaine, M.T.; Lockwood, M.A.; Natchus, M.G.; Liotta, D.C.; Plemper, R.K.; Snyder, J.P.; Sun, A. Asymmetric synthesis of host-directed inhibitors of myxovirus. Beilstein J. Org. Chem. 2013, 9 (23), 197-203.
          75. Kim, J.; Wang, L.; Li, Y.; Becnel, K.D.; Frey, K.M.; Garforth, S.J.; Prasad, V.R.; Schinazi, R.F.; Liotta, D.C.; Anderson, K.S. Pre-Steady State Kinetic Analysis of Cyclobutyl Derivatives of 2’-Deoxyadenosine 5’-Triphosphate as Inhibitors of HIV-1 Reverse Transcriptase. Bioorg. Med. Chem. Lett. 2012, 22 (12), 4064-4067.
          76. Hassam, M.; Basson, A.E.; Liotta, D.C.; Morris, L.; van Otterlo, W.A.L.; Pelly, S.C. Novel Cyclopropyl-Indole Derivatives as HIV Non-Nucleoside Reverse Transcriptase Inhibitors. ACS Med. Chem. Lett. 2012, 3 (6), 470-475.
          77. Guthrie, D.B.; Stein, D.G.; Liotta, D.C.; Lockwood, M.A.; Sayeed, I.; Atif, F.; Arrendale, R.F.; Reddy, G.P.; Evers, T.J.; Marengo, J.R.; Howard, R.B.; Culver, D.G.; Natchus, M.G. Water-Soluble Progesterone Analogues are Effective, Injectable Treatments in Animal Models of Traumatic Brain Injury. ACS Med. Chem. Lett. 2012, 3 (5), 362-366.
          78. Burger, P.B.; Yuan, H.; Karakas, E.; Geballe, M.; Furkawa, H.; Liotta, D.C.; Snyder, J.P.; Traynelis, S.F. Mapping the Binding of GluN2B-Selectve N-Methyl-D-Aspartate Receptor Negative Allosteric Modulators. Mol. Pharmacol. 2012, 82 (2), 344-359.
          79. Santangelo, R.M.; Acker, T.M.; Zimmerman, S.S.; Katzman, B.M.; Strong, K.L.; Traynelis, S.F.; Liotta, D.C. Novel NMDA Receptor Modulators: An Update. Expert Opin. Ther. Pat. 2012, 22 (11), 1337-1352.
          80. Meyer, E.V.S.; Holt, J.J.; Girard, K.R.; Ballie, M.T.; Bushnev, A.S.; Lapp, S.; Menaldino, D.S.; Arrendale, R.F.; Reddy, G.P.; Evers, T.J.; Howard, R.B.; Culvers, D.G. Liotta, D.C.; Galinski, M.R.; Natchus, M.G. Sphingolipid Analogues Inhibit Development of Malaria Parasites. ACS Med. Chem. Lett. 2012, 3 (1), 43-47.
          81. Liang, Z.; Zhan, W.; Zhu, A.; Yoon, Y.; Lin, S.; Sasaki M.; Klapproth, J.M.A.; Yang, H.; Grossniklaus, H.E.; Xu, J.; Rojas, M.; Voll, R.J.; Goodman, M.M.; Arrendale, R.F.; Liu, J.; Yun, C.C.; Snyder, J.P.; Liotta, D.C.; Shim, H. Development of a Unique Small Molecule Modulator of CXCR4. PLoS One. 2012, 7 (4), e34038.
          82. Ndungu, J.M.; Krumm, S.A.; Yan, D.; Arrendale, R.F.; Reddy, P.; Evers, T.; Howard, R.; Natchus, M.G.; Sandaine, M.T.; Liotta, D.C.; Plemper, R.K.; Snyder, J.P.; Sun, A. Non-Nucleoside Inhibitors of the Measles Virus RNA-dependent RNA Polymerase: Synthesis, Structure Activity Relationships and Pharmacokinetics. J. Med. Chem. 2012, 55 (9), 4220−4230.
          83. Olivera, A.; Moore, T.W.; Hu, F.; Brown, A.P.; Sun, A.; Liotta, D.C.; Snyder, J.P.; Yoon, Y.; Shim, H.; Marcus, A.I.; Miller, A.H.; Pace, T.W.W. Inhibition of the NF-κB Signaling Pathway by the Curcumin Analog, 3,5-Bis(2-Pyridinylmethylidene)-4-Piperidone (EF31): Anti-Inflammatory and Anti-Cancer Properties. Int. Immunopharmacol. 2012, 12 (2), 368-377.
          84. Boyle, G.A.; Edlin, C.D.; Li, Y.; Liotta, D.C.; Morgans, G.L.; Musonda, C.C. Enantioselective Synthesis of the Carbocyclic Nucleoside (–)-Abacavir. Org. Biomol. Chem. 2012, 10 (9), 1870-1876.
          85. Makarova, N.; Zhao, C.; Zhang, Y.; Bhosle, S.; Suppiah, S.; Rhea, J.M.; Kozyr, N.; Arnold, R.S.; Ly, H.; Molinaro, R.J.; Parslow, T.G.; Hunter, E.; Liotta, D.; Petros, J.; Blackwell, J.L. Antibody Responses Against Xenotropic Murine Leukemia Virus-Related Virus Envelope in a Murine Model. PLoS One. 2011, 6 (4), e18272.
          86. Zhan, W.; Jiang, Y.; Sharma, S.; Brodie, P.J.; Bane, S.; Kingston, D.G.I.; Liotta, D.C.; Snyder, J.P. C6-C8 Bridged Epothilones: Consequences of Installing a Conformational Lock at the Edge of the Macrocycle Chem. Eur. J. 2011, 17 (52), 14792-14804.
          87. Wilson, L.J.; Liotta, D.C. Emergence of Small-Molecule CXCR4 Antagonists as Novel Immune and Hematopoietic System Regulatory Agents. Drug Develop. Res. 2011, 72 (7), 598-602.
          88. Symolon, H.; Bushnev, A.; Peng, Q.; Ramaraju, H.; Mays, S.; Allegood, J.; Pruett, S.; Sullards, M.C.; Dillehay, D.L.; Liotta, D.C.; Merrill, A.H. Enigmol: A Novel Sphingolipid Analogue with Anticancer Activity against Cancer Cell Lines and In Vivo Models for Intestinal and Prostate Cancer. Mol. Cancer Ther. 2011, 10 (4), 648-657.
          89. Acker, T.M.; Yuan, H.; Hansen, K.B.; Vance, K.M.; Ogden, K.K.; Jensen, H.S.; Burger, P.B.; Mullasseril, P.; Snyder, J.P.; Liotta, D.C.; Traynelis, S.F. Mechanism for Noncompetitive Inhibition by Novel GluN2C/D N-Methyl-D-Aspartate Receptor Subunit-selective Modulators. Mol. Pharmacol. 2011, 80 (5), 782-795.
          90. Garnier-Amblard, E.C.; Mays, S.G.; Arrendale, R.F.; Baillie, M.T.; Bushnev, A.S.; Culver, D.G.; Evers, T.J.; Holt, J.J.; Howard, R.B.; Liebeskind, L.S.; Menaldino, D.S.; Natchus, M.G.; Petros, J.A.; Ramaraju, H.; Reddy, G.P.; Liotta, D.C. Novel Synthesis and Biological Evaluation of Enigmols as Therapeutic Agents for Treating Prostate Cancer. ACS Med. Chem. Lett. 2011, 2 (6), 438-443.
          91. Bushnev, A.S.; Baillie, M.T.; Holt, J.J.; Menaldino, D.S.; Merrill, A.H.; Liotta, D.C. An Efficient Asymmetric Synthesis of Enigmols (1-Deoxy-5-Hydroxysphingoid Bases), An Important Class of Bioactive Lipid Modulators. ARKIVOC (Gainesville, FL, United States). 2010, (8), 263-277.
          92. Pandey, K.K.; Snyder, J.P.; Liotta, D.C.; Musaev, D.G. Computational Studies of Transition Metal Selectivity of Octapeptide Repeat Region of Prion Protein (PrP). J. Phys. Chem. B. 2010, 114 (2), 1127-1135.
          93. Zhu, A.; Zhan, W.; Liang, Z.; Yoon, Y.; Yang, H.; Grossniklaus, H.E.; Xu, J.; Rojas, M.; Lockwood, M.; Snyder, J.P.; Liotta, D.C.; Shim, H. Dipyrimidine Amines: A Novel Class of Chemokine Receptor Type 4 Antagonists with High Specificity. J. Med. Chem. 2010, 53 (24), 8556-8568.
          94. Heathcote, D.A.; Patel, H.; Kroll, S.H.B.; Hazel, P.; Periyasamy, M.; Alikian, M.; Kanneganti, S.K.; Jogalekar, A.S.; Scheiper, B.; Barbazanges, M.; Blum, A.; Bräckow, J.; Siwicka, A.; Pace, R.D.M.; Fuchter, M.J.; Snyder, J.P.; Liotta, D.C.; Freemont, P.S.; Aboagye, E.O.; Coombes, R.C.; Barrett, A.G.M.; Ali, S. A Novel Pyrazolo[1,5- a]pyrimidine is a Potent Inhibitor of Cyclin-Dependent Protein Kinases 1, 2 and 9, which Demonstrates Antitumor Effects in Human Tumor Xenografts Following Oral Administration. J. Med. Chem. 2010, 53 (24), 8508-8522.
          95. Thomas, S.L.; Zhao, J.; Li, Z.; Lou, B.; Du, Y.; Purcell, J.; Snyder, J.P.; Khuri, F.R.; Liotta, D.; Fu, H. Activation of the p38 Pathway by A Novel Monoketone Curcumin Analog, EF24, Suggests A Potential Combination Strategy. Biochem. Pharmacol. 2010, 80 (9), 1309-1316.
          96. Tan, X.; Sidell, N.; Mancini, A.; Huang, R.; Wang, S.; Horowitz, I.R.; Liotta, D.C.; Taylor, R.N.; Wieser, F. Multiple Anticancer Activities of EF24, a Novel Curcumin Analog, on Human Ovarian Carcinoma Cells. Reprod. Sci. 2010, 17 (10), 931-940.
          97. Mullasseril, P.; Hansen, K.B.; Vance, K.M.; Ogden, K.K.; Yuan, H.; Kurtkaya, N.L.; Santangelo, R.; Orr, A.G.; Le, P.; Vellano, K.M.; Liotta, D.C.; Traynelis, S.F. A Subunit-Selective Potentiator of NR2C- and NR2D-Containing NMDA Receptors. Nat. Commun. 2010, 1 (90), 1-8.
          98. Arnold, R.S.; Makarova, N.V.; Osunkoya, A.O.; Suppiah, S.; Scott, T.A.; Johnson, N.A.; Bhosle, S.M.; Liotta, D.; Hunter, E.; Marshall, F.F.; Ly, H.; Mollinaro, R.J.; Blackwell, J.L.; Petros, J.A. XMRV Infection in Patients with Prostate Cancer: Novel Serologic Assay and Correlation with PCR and FISH. Urol. 2010, 75 (4), 755-761.
          99. Li, Y.; Soni, P.B.; Liu, L.; Zhang, X.; Liotta, D.C.; Lutz, S. Synthesis of Fluorescent Nucleoside Analogs as Probes for 2’-Deoxyribonucleoside Kinases. Bioorg. Med. Chem. Lett. 2010, 20 (3), 841-843.
          100. Bhosle, S.; Suppiah, S.; Molinaro, R.; Liang, Y.; Arnold, R.; Diehl, W.; Makarova, N.; Blackwell, J.; Petros, J.; Liotta, D.; Hunter, E.; Ly, H. Evaluation of Cellular Determinants Required for In Vitro Xenotropic Murine Leukemia Virus-Related Virus Entry into Human Prostate Cancer and Noncancerous Cells. J. Virol. 2010, 84 (13), 6288-6296.
          101. Mosley, C.A.; Acker, T.M.; Hansen, K.B.; Mullasseril, P.; Andersen, K.T.; Le, P.; Vellano, K.M.; Bräuner-Osborne, H.; Liotta, D.C.; Traynelis, S.F. Quinazolin-4-one derivatives: A Novel Class of Noncompetitive NR2C/D Subunit-Selective N-methyl-D-aspartate Receptor Antagonists. J. Med. Chem. 2010, 53 (15), 5476-5490.
          102. Sun, A.; Lu, Y.; Hu, H.; Shoji, M.; Liotta, D.C.; Snyder, J.P. Curcumin Analog Cytotoxicity Against Breast Cancer Cells: Exploitation of a Redox-Dependent Mechanism. Bioorg. Med. Chem. Lett. 2009, 19 (23), 6627-6631.
          103. Liu, L.; Li, Y.; Liotta, D.; Lutz, S. Directed Evolution of an Orthogonal Nucleoside Analog Kinase via Fluorescence-Activated Cell Sorting. Nucleic. Acids Res. 2009, 37 (13), 4472-4481.
          104. Mosley, C.A.; Wilson, L.J.; Wiseman, J.M.; Skudlarek, J.W.; Liotta, D.C. Recent Patents Regarding the Discovery of Small Molecule CXCR4 Antagonists. Expert Opin. Ther. Patents. 2009, 19 (1), 23-28.
          105. Ali, S.; Heathcote, D.A.; Kroll, S.H.B.; Jogalekar, A.S.; Scheiper, B.; Patel, H.; Brackow, J.; Siwicka, A.; Fuchter, M.J.; Periyasamy, M.; Tolhurst, R.S.; Kanneganti, S.K.; Snyder, J.P.; Liotta, D.C.; Aboagye, E.O.; Barrett, A.G.M.; Coombes, R.C. The Development of a Selective Cyclin-Dependent Kinase Inhibitor That Shows Antitumor Activity. Cancer Res. 2009, 69 (15), 6208-6215.
          106. Mosley, C.A.; Myers, S.J.; Murray, E.E.; Santangelo, R.; Tahirovic, Y.A.; Kurtkaya, N.; Mullasseril, P.; Yuan, H.; Lyuboslavsky, P.; Le, P. Wilson, L.J.; Yepes, M.; Dingledine, R.; Traynelis, S.F.; Liotta, D.C. Synthesis, Structural Activity-Relationships, and Biological Evaluation of Novel Amide-Based Allosteric Binding Site Antagonists in NR1A/NR2B N-Methyl-D-Aspartate Receptors. Bioorg. Med. Chem. 2009, 17 (17), 6463-6480.
          107. MacNevin, C.J.; Atif, F.; Sayeed, I.; Stein, D.G.; Liotta, D.C. Development and Screening of Water-Soluble Analogues of Progesterone and Allopregnanolone in Models of Brain Injury. J. Med. Chem. 2009, 52 (19), 6012-6023.
          108. Kasinski, A.L.; Du, Y.; Thomas, S.L.; Zhao, J.; Sun, S.; Khuri, F.R.; Wang, C.; Shoji M., Sun, A.; Snyder, J.P.; Liotta, D.; Fu, H. Inhibition of IκB Kinase-Nuclear Factor-κB Signaling Pathway by 3,5-Bis-(2-flurobenzylidene)piperidin-4-one (EF24), A Novel Monoketone Analog of Curcumin. Mol. Pharmacol. 2009, 74 (3), 654-661.
          109. Thepchatri, P.; Min, J.; Ganesh, T.; Du, Y.; Lewis, I.; Kurtkaya, S.; Prussia, A.; Li, L.; Plemper, R.K.; Fu, H.; Liotta, D.C.; Snyder, J.P.; Dingledine, R.; Sun, A. Cancer and Virus Leads by HTS, Chemical Design and SEA Data Mining. Curr. Top. Med. Chem. 2009, 9 (13), 1159-1171.
          110. Thomas, S.L.; Zhong, D.; Zhou, W.; Malik, S.; Liotta, D.; Snyder, J.P.; Hamel, E.; Giannakakou, P. EF24, A Novel Curcumin Analog, Disrupts the Microtubule Cytoskeleton and Inhibits HIF- 1. Cell Cycle. 2008, 7 (15), 2409-2417.
          111. Pruett, S.T.; Bushnev, A.; Hagedorn, K.; Adiga, M.; Haynes, C.A.; Sullards, M.C.; Liotta, D.C.; Merrill, A.H. Biodiversity of Sphingoid Bases (“Sphingosines”) and Related Amino Alcohols. J. Lipid Res. 2008, 49 (8), 1621-1639.
          112. Altas Tahirovic, Y.; Geballe, M.; Gruszecka-Kowalik, E.; Myers, S.J.; Lyuboslavsky, P.; Le, P.; French, A.; Irier, H.; Choi, W.B.; Easterling, K.; Yuan, H.; Wilson, L.J.; McNamara, J.O.; Dingledine, R.; Liotta, D.C.; Traynelis, S.F.; Snyder, J.P. Enantiomeric Propanolamines as Selective N-Methyl-D-Aspartate 2B Receptor Antagonists. J. Med. Chem. 2008, 51 (18), 5506-5521.
          113. Zhan, W.; Jiang, Y.; Brodie, P.J.; Kingston, D.G.I.; Liotta, D.C.; Snyder, J.P. Design and Synthesis of C6- C8 Bridged Epothilone A. Org. Lett. 2008, 10 (8), 1565-1568.
          114. Shoji, M.; Sun, A.; Kisiel, W.; Lu, Y.L.; Shim, H.; McCarey, B.E.; Nichols, C.; Parker, E.T.; Pohl, J.; Mosley, C.A.; Alizadeh, A.R.; Liotta, D.C.; Snyder, J.P. Targeting Tissue Factor-Expressing Tumor Angiogenesis and Tumors with EF24 Conjugated to Factor VIIa. J. Drug Targeting. 2008, 16 (3), 185-197.
          115. MacNevin, C.J.; Moore, R.L.; Liotta, D.C. Stereoselective Synthesis of Quaternary Center Bearing Azetines and their β-Amino Acid Derivatives. J. Org. Chem. 2008, 73 (4), 1264-1269.
          116. Ganesh, T.; Min, J.; Thepchatri, P.; Du, Y.; Li, L.; Lewis, I.; Wilson, L.; Fu, H; Chiosis, G.; Dingledine, R.; Liotta, D.; Snyder J.P.; Sun, A. Discovery of Aminoquinolines as A New Class of Potent Inhibitors of Heat Shock Protein 90 (Hsp90): Synthesis, Biology, and Molecular Modeling. Bioorg. Med. Chem. Lett. 2008,16 (14), 6903-6910.
          117. Zhan, W.; Liang, Z.; Zhu, A.; Kurtkaya, S.; Shim, H.; Snyder, J.P.; Liotta, D.C. Discovery of Small Molecule CXCR4 Antagonists. J. Med. Chem. 2007, 50 (23), 5655-5664.
          118. Li, Y.; Mao, S.; Hager, M.W.; Becnel, K.D.; Schinazi, R.F.; Liotta, D.C. Synthesis and Evaluation of 2′-Substituted Cyclobutyl Nucleosides and Nucleotides as Potential Anti-HIV Agents. Biooorg. Med. Chem. Lett. 2007, 17 (12), 3398-3401.
          119. Wiseman, J.M.; McDonald, F.E.; Liotta, D.C. 1-Deoxy-5-Hydroxysphingolipids as New Anticancer Principles: An Efficient Procedure for Stereoselective Syntheses of 2-Amino-3, 5-Diols. Org. Lett. 2007, 9 (15), 2959.
          120. Mosley, C.A.; Liotta, D.C.; Snyder, J.P. Highly Active Anti-Cancer Curcumin Analogs. Adv. Exp. Med. Biol. 2007, 595, 77-103. (Aggarwal, B.; Surh, B.; Shishoda, Y. Eds.).
          121. Herold-Dublin, M.; Liotta, D.C. Diastereoselective Addition of Chlorotitanium Enolates of N-Acyl Thiazolidinethione to Activated Imines: A Novel Synthesis of β-Lactams. Can. J. Chem., 2006, 84 (12), 1696-1699.
          122. Sun, A.; Prussia, A.; Zhan, W.; Murray, E.E.; Doyle, J.; Cheng, L.T.; Yoon, J.J.; Radchenko, E.V.; Palyulin, V.A.; Compans, R.W.; Liotta, D.C.; Plemper, R.K.; Snyder, J.P. Nonpeptide Inhibitors of Measles Virus Entry. J. Med. Chem. 2006, 49 (17), 5080-5092.
          123. Sun, A.; Shoji, M.; Lu, Y.J.; Yang, J.L.; Liotta, D.C.; Snyder, J.P. Synthesis of EF24-Tripeptide Chloromethyl Ketone: A Novel Curcumin-Related Anticancer Drug Delivery System. J. Med. Chem. 2006, 49 (11), 3153-3158.
          124. Dougherty, A.M.; McDonald, F.E.; Liotta, D.C.; Moody, S.J.; Pallas, D.C.; Pack, C.D.; Merrill, A.H. Synthesis of 1-Deoxysphingosine Derivatives with Conformationally Restricted Pyrrolidinediol Head Groups. Org. Lett. 2006, 8 (4), 649-652.
          125. Doyle, J.; Prussia, A.; White, L.K.; Sun, A.; Liotta, D.C.; Snyder, J.P.; Compans, R.W.; Plemper, R.K. Two Domains that Control Prefusion Stability and Transport Competence of the Measles Virus Fusion Protein. J. Virol. 2006, 80 (3), 1524-1536.
          126. Wiseman, J.M.; McDonald, F.E.; Liotta, D.C. 1-Deoxy-5-hydroxysphingolipids as New Anticancer Principles: An Efficient Procedure for Stereoselective Syntheses of 2-Amino-3,5-diols. Org. Lett. 2005, 7 (15), 3155-3157.
          127. Plemper, R.K.; Doyle, J.; Sun, A.; Prussia, A.; Cheng, L.; Rota, P.A.; Liotta, D.C.; Snyder, J.P.; Compans, R.W. Design of a Small-Molecule Entry Inhibitor with Activity Against Primary Measles Virus Strains. Antimicrob. Agents Chemother. 2005, 49 (9), 3755-3761.
          128. Adams, B.K.; Cai, J.; Armstrong, J.; Herold, M.; Lu, Y.J.; Sun, A.; Snyder, J.P.; Liotta, D.C.; Jones, D.P.; Shoji, M. EF24, A Novel Synthetic Curcumin Analog, Induces Apoptosis in Cancer Cells via a Redox-Dependent Mechanism. Anti-Cancer Drugs. 2005, 16 (3), 263-275.
          129. Hernandez-Santiago, B.I.; Chen, H.; Asif, G.; Beltran, T.; Mao, S.; Hurwitz, S.J.; Grier, J.; McClure, H.M.; Chu, C.K.; Liotta, D.C.; Schinazi, R.F. Pharmacology and Pharmacokinetics of the Antiviral Agent ß-D-2′,3′-Dideoxy-3′-Oxa-5-Fluorocytidine in Cells and Rhesus Monkeys. Antimicrob. Agents Chemother. 2005, 49 (7), 2589-2597.
          130. Adams, B.K.; Ferstl, E.M.; Davis, M.C.; Herold, M.; Kurtkaya, S.; Camalier, R.F; Hollingshead, M.G.; Kaur, G.; Sausville, E.A.; Rickles, F.R; Snyder, J.P.; Liotta, D.C.; Shoji, M. Synthesis and Biological Evaluation of Novel Curcumin Analogs as Anti-Cancer and Anti-Angiogenesis Agents. Bioorg. Med. Chem. 2004, 12 (14), 3871-3883.
          131. Ambhaikar, N.B.; Herold, M.; Liotta, D.C. A Uniquely Accessible Route to the Diastereoselective Synthesis of Azetine Derivatives, Heterocycles. 2004, 62, 217-222.
          132. Plemper, R.K.; Erlandson, K.J.; Lakdawala, A.S.; Sun, A.; Prussia, A.; Boonsombat, J.; Aki-Sener, E.; Yalcin, I.; Yildiz, I.; Temiz-Arpaci, O.; Tekiner, B.; Liotta, D.C.; Snyder, J.P.; Compans, R.W. A Target Site for Template-Based Design of Measles Virus Entry Inhibitors. Proc. Natl. Acad. Sci. U.S.A. 2004, 101 (15), 5628-5633.
          133. Painter, G.R.; Almond, M.R.; Mao, S.; Liotta, D.C. Biochemical and Mechanistic Basis for the Activity of Nucleoside Analogue Inhibitors of HIV Reverse Transcriptase. Curr.Top. Med. Chem. 2004, 4 (10), 1035-1044.
          134. Mao, S.; Bouygues, M.; Welch, C.; Biba, M.; Chilenski, J.; Schinazi, R.F.; Liotta, D.C. Synthesis of Enantiomerically Pure D-FDOC, an Anti-HIV Agent. Bioorg. Med. Chem. Lett. 2004, 14 (19), 4991-4994.
          135. Menaldino, D.S.; Bushnev, A.; Sun, A.; Liotta, D.C.; Symolon, H.; Desai, K.; Dillehay, D.L.; Peng, Q.; Wang, E.; Allegood, J.; Trotman-Pruett, S.; Sullards, M.C.; Merrill, A.H. Sphingoid Bases and De Novo Ceramide Synthesis: Enzymes Involved, Pharmacology and Mechanisms of Action. Pharm. Res. 2003, 47 (5), 373-381.
          136. Guindon, Y.; Ogilvie, W.W.; Bordeleau, J.; Cui, W.L.; Durkin, K.; Gorys, V.; Juteau, H.; Lemieux, R.; Liotta, D.; Simoneau, B.; Yoakim, C. Opening of Tartrate Acetals Using Dialkylboron Bromide: Evidence for Stereoselectivity Downstream from Ring Fission, J. Am. Chem. Soc. 2003,125 (2), 428-436.
          137. Painter, G.R.; Rimsky, L.T.; Furman, P.A.; Liotta, D.C.; Schinazi, R.F.; Quinn, J.B. Preclinical and Clinical Development of the anti-HIV, anti-HBV Oxathiolane Nucleoside Analog Emtricitabine. Front. Vir. Hep. 2003, 451-484.
          138. Ambhaikar, N.B.; Snyder, J.P.; Liotta, D.C. Diastereoselective Addition of Chlorotitanium Enolate of N-Acyl Thiazolidinethione to O-Methyl Oximes: A Novel, Stereoselective Synthesis of α,β-Disubstituted β-Amino Carbonyl Compounds via Chiral Auxiliary Mediated Azetine Formation. J. Am. Chem. Soc. 2003, 125 3690-3691.
          139. Merrill, A.H.; Sullards, M.C.; Allegood, J.C.; Wang, E.; Linn, S.C.; Andras, L.; Liotta, D.C.; Hartl, M.; Humpf, H. Insights into the Modulation of Ceramide Metabolism by Naturally Occurring and Synthetic Sphingolipid Analogs as Monitored by Electrospray Tandem Mass Spectrometry. Ceramide Signaling. 2002, ISBN: 0-306-47442-5. (Futerman, A. H. Ed. Landes Bioscience Pub.).
          140. Lakdawala, A.S.; Morgan, D.M.; Liotta, D.C.; Lynn, D.G.; Snyder, J.P. Dynamics and Fluidity of Amyloid Fibrils: A Model of Fibrous Protein Aggregates, J. Am. Chem. Soc. 2002, 124 (51), 15150-15151.
          141. Morgan, D.M.; Lynn, D.G.; Lakdawala, A.S.; Snyder, J.P.; Liotta, D.C. Amyloid Structure: Models and Theoretical Considerations in Fibrous Aggregates. J. Chin. Chem. Soc. (Taipei, Taiwan). 2002, 49 (4), 459-466.
          142. Ferstl, E.M.; Venkatesan, H.; Ambhaikar, N.B.; Snyder, J.P.; Liotta, D.C. Thiazolidine-2-thione Directed Diastereoselective Addition of Chlorotitanium Enolates to Aldimines. Synthesis. 2002, (14), 2075-2083.
          143. Painter, G.R.; Anderson, K.; Bouygues, M.; Joubert, M.; Liotta, D. Virally Encoded Polymerases as Targets for Chemotherapy: Application to HIV and HBV. Curr. Med. Chem.: Anti-Infective Agents. 2002, 1 (2), 99-117.
          144. Schinazi, R.F.; Mellors, J.; Bazmil, H.; Diamond, S.; Garber, S.; Gallagher, K.; Geleziunas, R.; Klabe, R.; Pierce, M.; Rayner, M.; Wu, J.; Zhang, H.; Hammond, J.; Bacheler, L.; Manion, D.J.; Otto, M.J.; Stuyver, L.; Trainor, G.; Liotta, D.C.; Erikson-Viitanen, S. DPC 817: A Cytidine Nucleoside Analog with Activity Against Zidovudine- and Lamivudine-Resistant Viral Variants. Antimicrob. Agents Chemother. 2002, 46 (5), 1394-1401.
          145. Desai, K.; Sullards, M.C.; Allegood, J.; Wang, E.; Schmelz, E.M.; Hartl, M.; Humpf, H.; Liotta, D.C.; Peng, Q.; Merrill, A.H. Fumonisins and Fumonisin Analogs as Inhibitors of Ceramide Synthase and Inducers of Apoptosis. Biochem. Biophys. Acta. 2002, 1585 (2-3), 188-192.
          146. Nicolaou, K.C.; Namoto, K.; Ritzen, A.; Ulven, T.; Shoji, M.; Li, J.; D’Amico, G.; Liotta, D.; French, C.T.; Wartmann, M.; Altmann, K.; Giannakakou, P. Chemical Synthesis and Biological Evaluation of cis- and trans- 12,13-Cyclopropyl and 12,13-Cyclobutyl Epothilones and Related Pyridine Side Chain Analogues. J. Am. Chem. Soc. 2001, 123 (38), 9313-9323.
          147. Schinazi, R.F.; Hurwitz, S.J.; Liberman, I.; Juodawlkis, A.; Shi, J.; Liotta, D.C.; Coderre, J.; Olson, J. Preclinical Development of β-D-5-o-Carboranyl-2’-Deoxyuridine (D-CDU) for the Treatment of Malignant Brain Tumors. Frontiers in Neutron Capture Therapy (Hawthorne et al., Ed.). 2001, 2, 1121-1124.
          148. Lakdawala, A.; Wang, M.; Nevins, N.; Liotta, D.C.; Rusinska-Roszak, D.; Lozynski, M.; Snyder, J.P. Calculated Conformer Energies for Organic Molecules with Multiple Polar Functionalities are Method Dependent: Taxol (Case Study). BMC Chem. Biol. 2001, 1:2.
          149. Judd, D.A.; Nettles, J.H.; Nevins, N.; Snyder, J.P.; Liotta, D.C.; Tang, J.; Ermolieff, J.; Schinazi, R.F.; Hill, C.L. Polyoxometalate HIV-1 Protease Inhibitors. A New Mode of Protease Inhibition. J. Am. Chem. Soc. 2001, 123 (5), 886-897.
          150. Venkatesan, H.; Davis, M.C.; Snyder, J.P.; Liotta, D.C. Total Synthesis of SR 121463 A, a Highly Potent and Selective Vasopressin V2 Receptor Antagonist. J. Org. Chem. 2001, 66 (11), 3653-3661.
          151. Wang, M.; Cornett, B.; Nettles, J.; Liotta, D.C.; Snyder, J.P. The Oxetane Ring in Taxol. J. Org. Chem. 2000, 65 (4), 1059-1068.
          152. Schinazi, R.F.; Hurwitz, S.J.; Liberman, I.; Juodawlkis, A.S.; Tharnish, P.; Shi, J.; Liotta, D.C.; Coderre, J.A.; Olson, J. Treatment of Isografted 9L Rat Brain Tumors with β-5-ο-Carboranyl-2’-Deoxyuridine Neutron Capture Therapy. Clin. Cancer Res. 2000, 6 (2), 725-730.
          153. Curfman, C.; Liotta, D. Synthesis of Sphingosine and Sphingoid Bases. Methods Enzymology: Sphingolipid Metabolism and Cell Signaling. 2000, 311, 391-440. (Merrill, A.; Hannun, Y. Eds.).
          154. Bushnev, A.S.; Liotta, D.C. Practical Synthesis of N-Palmitoylsphingomyelin and N-Palmitoyldihydrosphingomyelin. Methods in Enzymology: Sphingolipid Metabolism and Cell Signaling. 2000, 311, 535-546. (Merrill, A.; Hannun, Y. Eds.).
          1. Wang, M.; Xia, D.; Kim, Y.; Hwang, D.; Jansen, J.M.; Botta, M.; Liotta, D.C.; Snyder, J.P. A Unified and Quantitative Receptor Model for the Microtubule Binding of Paclitaxel and Epothilone. Org. Lett. 1999, 1 (1), 43-46.
          2. Schmelz, E.M.; Bushnev, A.S.; Dillehay, D.L.; Sullards, M.C.; Liotta, D.C.; Merrill, A.H. Ceramide β-D- glucuronide: Synthesis, Digestion and Suppression of Early Markers of Colon Carcinogenesis. Cancer Res. 1999, 59 (22), 5768-5772.
          3. Warden, L.A.; Menaldino, D.S.; Wilson, T.; Liotta, D.C.; Smith, E.R.; Merrill, A.H. Identification of Ammonium Ion and 2,6-bis-(ω-aminobutyl)-3,5-diimino-piperazine as Endogenous Factors that Account for the “Burst” of Sphingosine upon Changing the Medium of J774 Cells in Culture. J. Biol. Chem. 1999, 275 (48), 33875-33880.
          4. Ma, L.; Hurwutz, S.J.; Shi, J.; McAtee, J.J.; Liotta, D.C.; McClure, H.M.; Schinazi, R.F. Pharmacokinetics of the Antiviral Agent ß-D-2’,3’-Didehydro-2’,3’-Dideoxy-5-Fluorocytidine in Rhesus Monkeys. Antimicrob. Agents Chemother. 1999, 43 (2), 381-384.
          5. Shi, J.; McAtee, J.J.; Schlueter Wirtz, S.; Tharnish, P.; Juodawlkis, A.; Liotta, D.C.; Schinazi, R.F. Synthesis and Biological Evaluation of 2’,3’-Didehydro-2’,3’-dideoxy-5-fluorocytidine (D4FC) Analogues: Discovery of Carbocyclic Nucleoside Triphosphates with Potent Inhibitory Activity Against HIV-1 Reverse Transcriptase. J. Med. Chem. 1999, 42 (5), 859-867.
          6. McAtee, J.J.; Schinazi, R.F.; Liotta, D.C. A Completely Diastereoselective Electrophilic Fluorination of a Chiral, Noncarbohydrate Sugar Ring Precursor: Application to the Synthesis of Several Novel 2’-Fluoronucleosides. J. Org. Chem. 1998, 63 (7), 2161-2167.
          7. Birt, D.F.; Merrill, A.H.; Barnett, T.; Enkvetchakul, B.; Pour, P.M.; Liotta, D.C.; Geisler, V.; Menaldino, D.S.; Schwartzbauer, J. Inhibition of Skin Carcinomas but not Papillomas by Sphingosine, N-Methylsphingosine, and N-Acetyl Sphingosine. Nutr. & Cancer. 1998, 31 (2), 119-126.
          8. Humpf, H.U.; Schmelz, E.M.; Meredith, F.I.; Vesper, H.; Vales, T.R.; Menaldino, D.S.; Liotta, D.C.; Merrill, A.H. Acylation of Naturally Occurring and Synthetic 1-Deoxysphinganines by Ceramide Synthase: Formation of N-Palmitoyl-aminopentol Produces a Toxic Metabolite of Hydrolyzed Fumonisin AP1, and A New Category of Ceramide Synthase Inhibitor. J. Biol. Chem. 1998, 273 (30), 19060-19064.
          9. Snyder, J.; Xia, X.; Schestopol, M.; Kim, Y.; Bray, D.; Cain, M.; Liotta, D.; Koehler, K.; Jansen, Minireceptors for Molecular Design. Rational Molecular Design in Drug Research. 1998, 115-135. (Liljefors, T.; Jorgenson, F.S.; Krogsgaard-Larsen, P. Eds. Munksgaard, Copenhagen).
          10. Schinazi, R.F.; McMillan, A.; Lloyd, R.L.; Schuleter-Wirtz, S.; Liotta, D.C.; Chu, C.K. Molecular Properties of HIV-1 Resistant to (+) -Enantiomers and Racemates of Oxathiolane Cytosine Nucleosides and their Potential for the Treatment of HIV and HBV Infections. Antiviral Res. 1997, 34 (2).
          11. Nikolova-Karakashian, M.; Morgan, E.T.; Alexander, C.; Liotta, D.C.; Merrill, A.H. Bimodal Regulation of Ceramidase by Interleukin-1β: Implications for the Regulation of Cytochrome P450 2C11 (CYP2C11). J. Biol. Chem. 1997, 272 (30), 18718-18724.
          12. Xia, X.; Wang, J.; Hager, M.W.; Sisti, N.; Liotta, D.C. Stereocontrolled Synthesis of β-2’- Deoxypyrimidine Nucleosides via Intramolecular Glycosylations. Tetrahedron Lett. 1997, 38 (7), 1111-1114.
          13. Schmelz, E.M.; Bushnev, A.S.; Dillehay, D.L.; Liotta, D.C.; Merrill, A.H. Suppression of Aberrant Colonic Crypt Foci by Synthetic Sphingomyelins with Saturated or Unsaturated Sphingoid Base Backbones. Nutr. Cancer. 1997, 28, 81-85.
          14. Kikolova-Karakashian, M.; Vales, T.; Wang, E.; Menaldino, D.; Alexander, C.; Goh, J.; Merrill, A.; Liotta, D. Ceramide Synthase and Ceramidases in the Regulation of Sphingolipid Base Metabolism. Sphingolipidmediated Signal Transduction. Molecular Biology Intelligence Unit. 1997, 159-172. (Hannun Y. A., Ed.).
          15. Goudgaon, N.; El-Kattan, Y.A.; Xia, X.; McAtee, J.; Soria, J.; Wey, S.; Liotta, D.C.; Schinazi, R.F. A General Synthetic Method of 5-Carboranyluracil Nucleosides with Potential Antiviral Activity and Use in Neutron Capture Therapy. Nucleosides and Nucleotides. 1997, 16 (12), 2133-2150.
          16. Merrill, A.H.; Liotta, D.C.; Riley, R.T. Fumonisins: Fungal Toxins that Shed Light on Sphingolipid Function. Trends Cell Biol. 1996, 6 (6), 218-223.
          17. Alexander, C.W.; Liotta, D.C. A Diastereoselective Synthesis of (2S, 3R, 4S)-Amino-1-cyclohexyl-6-methylheptane-3,4-diol, the Abbott Aminodiol. Tetrahedron Lett. 1996, 37 (12), 1961-1964.
          18. Captain, L.F.; Xia, X.; Liotta, D.C. Remote Asymmetric Induction in Organocopper Conjugate Additions to 3-Ketoacrylates. Tetrahedron Lett. 1996, 37 (25), 4293-4296.
          19. Merrill, A.H.; Liotta, D.C.; Riley, R.E. Bioactive Properties of Sphingosine and Structurally Related Compounds. Handbook of Lipid Research, Lipid Second Messengers. 1996, 8, 205-237.
          20. Merrill, A.; Liotta, D.; Riley, R. Sphingolipid Analog Biomodulators in Foods Alter Sphingolipid Metabolism. Implications for Health and Disease. Proc. Nutri. Soc. Australia. 1996, 20, 124.
          21. Merrill, Jr., A.H.; Liotta, D.C.; Riley, R.T. Sphingolipids as Regulators of Cellular Growth, Differentiation, and Behavior. Adv. Lipobiol. 1996, 1, 273-298.
          22. Merrill, A.H.; Wang, E.; Vales, T.R.; Smith, E.R.; Schroeder, J.J.; Menaldino, D.S.; Alexander, C.; Crane, H.M.; Xia, J.; Liotta, D.C.; Meredith, F.I.; Riley, R.T. Fumonisin Toxicity and Sphingolipid Biosynthesis. Proceedings of the ACS Symposium on Fumonisins in Food (April 2-7, 1995, Anaheim, CA), Adv. Exp. Med. Biol. 1996, 392, 297-306.
          23. Liotta, D.; Jones, D. Origins of the Enantioselectivity Observed in Oxazaborolidine-Catalyzed Reductions of Ketones. Adv. Mol. Modeling. 1995, 3, 1-19.
          24. Jones, D.; Liotta, D. Episulfonium Ions May Not Be the Stereodeterminants in Glycosylations of 2-Thioalkyl Pyranosides. Adv. Mol. Modeling. 1995, 3, 67-98.
          25. Choi, W.B.; Churchill, H.R.O.; Lynch, J.E.; Volante, R.P.; Reider, P.J.; Shinkai, I.; Jones, D.K.; Liotta, D.C. An Unusual Stereoselective Decarboxylation: A Key Reaction to an Important Intermediate for Carbapenem Antibiotics. J. Org. Chem. 1995, 60 (26), 8367-8370.
          26. Xie, H.; Voronkov, M.; Liotta, D.C.; Korba, B.A.; Schinazi, R.F.; Richman, D.D.; Hostetler, K.Y. Phosphatidyl-2′,3′-dideoxy-3’-Thiacytidine: Synthesis and Antiviral Activity in Hepatitis B and HIV-1 Infected Cells. Antiviral Res. 1995, 28 (2), 113-120.
          27. Wilson, L.J.; Hager, M.W.; El-Kattan, Y.A.; Liotta, D.C. Nitrogen Glycosylation Reactions Involving Pyrimidine and Purine Nucleoside Bases with Furanoside Sugars. Synthesis. 1995, 12, 1465-1479.
          28. Hoekstra, W.J.; Beavers, M.P.; Andrade-Gordon, P.; Evangelisto, M.F.; Keane, P.M.; Press, J.B.; Tomko, K.A.; Fan, F.; Kloczewiak, M.; Mayo, K.H.; Durkin, K.A.; Liotta, D.C. Design and Evaluation of Non-Peptide Fibrinogen Gamma Chain Based GPIIB/IIIA Antagonists. J. Med.Chem. 1995, 38 (10), 1582-1592.
          29. Pushkareva, M.; Chao, R.; Bielawska, A.; Merrill, A.H.; Crane, H.M.; Lagu, B.; Liotta, D.; Hannun, Y.A. Stereoselectivity of Induction of Retinoblastoma Gene Product (pRb) Dephosphorylation by D-erythro-Sphingosine Supports a Role for pRb in Growth Suppression by Sphingosine. Biochem. 1995, 34, 1885-1892.
          30. Dirsch, V.; Frederico, J.; Zhao, N.; Cai, G.; Chen, Y.; Vunnam, S.; Odingo, J.; Pu, H.; Nakanishi, K.; Berova, N.; Liotta, D.; Bielawska, A.; Hannun, Y. A Two-Step Chemical and Circular Dichroic Method for Assigning the Absolute Configurations of Sphingosines. Tetrahedron Lett. 1995, 36 (28), 4959-4962.
          31. Schroeder, J.J.; Crane, H.M.; Xia, J.; Liotta, D.C.; Merrill, A.H. Disruption of Sphingolipid Metabolism and Stimulation of DNA Synthesis by Fumonisin B1. A Molecular Mechanism for Carcinogenesis Associated with Fursarium Moniliforme. J. Biol. Chem. 1994, 269 (5), 3475-3481. PMID: 8106389
          32. Lagu, B.R.; Liotta, D.C. Diastereoselective Synthesis of the Key Lactone Intermediate for the Preparation of Hydroxyethylene Dipeptide Isosteres. Tetrahedron Lett. 1994, 35 (4), 547-550.
          33. Goh, J.B.; Lagu, B.R.; Wurster, J.; Liotta, D. Aldol Reactions of a-(N,N-Dibenzylamino) Ethyl Ketones. Tetrahedron Lett. 1994, 35 (33), 6029-6032.
          34. Jones, D.K.; Liotta, D.C.; Choi, W.B.; Volante, R.P.; Reider, P.J.; Shinkai, I.; Churchill, H.R.O.; Lynch, J.E. A Facially-Selective Protonation Controls the Stereochemistry of a Key Intermediate in the Synthesis of 1β-Methylcarbapenems. J. Org. Chem. 1994, 59 (14), 3749-3751.
          35. Jarugula, V.R.; Schinazi, R.F.; Fulcrand, G.; El Kattan, Y.E.; Liotta, D.C.; Boudinot, F.D. Pharmacokinetics of 5-Carboranyl-2’-Deoxyuridine in Rats. J. Pharm. Sci. 1994, 83 (12), 1697-1699. PMID: 789126
          36. Schinazi, R.F.; Gosselin, G.; Faraj, A.; Korba, B.E.; Liotta, D.C.; Chu, C.K.; Mathe, C.; Imbach, J.; Sommadossi, J. Pure Nucleoside Enantiomers of β-2′,3′-Dideoxycytidine Analogs are Selective Inhibitors of Hepatitis B Virus. In Vitro Antimicrob. Agents Chemother. 1994, 38 (9), 2172-2174.
          37. Hoekstra, W.J.; Press, J.B.; Bonner, M.P.; Andrade-Gordon, P.; Keane, P.M.; Durkin, K.A.; Liotta, D.C.; Mayo, K.H. Adamantane and Nipecotic Acid Derivatives as Novel β-Turn Mimics. Bio. Med. Chem. Lett. 1994, 4 (11), 1361-1364.
          38. Schinazi, R.F.; Goudgaon, N.M.; Fulcrand, G.; El-Kattan, Y.; Lesnikowski, Z.; Moravek, J.; Liotta, D.C. Cellular Pharmacology and Biological Activity of 5-Carboranyl-2’-Deoxyuridine. Int. J. Radiat. Oncol. Biol. Phys. 1994,  (5), 1113-1120.
          39. Abobo, C.V.; Ni, L.; Schinazi, R.F.; Liotta, D.C.; Boudinot, F.D. Pharmacokinetics of 2′,3′-Dideoxy-5-fluoro-3′-thiacytidine in Rats. J. Pharm. Sci. 1994, 83 (1), 96-99.
          40. Guindon, Y.; Yoakim, C.; Gorys, V.; Ogilvie, W.W.; Delorme, D.; Renaud, J.; Robinson, G.; Lavallee, J.F.; Slassi, A.; Jung, G.; Rancourt, J.; Durkin, K.; Liotta, D. Stereoselective Hydrogen Transfer Reactions Involving Acyclic Radicals. Tandem Substituted Tetrahydrofuran Formation and Stereoselective Reduction: Synthesis of the C17-C22 Subunit of Ionomycin. J. Org. Chem. 1994, 59 (5), 1166-1178.
          41. Lagu, B.R.; Liotta, D.C. Surprisingly High Diastereoselection in the Aldol Reactions of Sodium Enolates of a-Amino Methyl Ketones. Tetrahedron Lett. 1994, 35 (26), 4485-4488.
          42. El-Kattan, Y.; Goudgaon, N.; Fulcrand, G.; Liotta, D.; Schinazi, R. Synthesis of 5- Carboranyluracil and its Glycosylation with Normal and Modified Carbohydrates. Current Topics in the Chemistry of Boron (Royal Society of Chemistry), 1994, 181-4.
          43. Bielawska, A.; Crane, H.M.; Liotta, D.; Obied, L.M.; Hannun, Y.A. Selectivity of Ceramide-Mediated Biology: Lack of Activity of Erthro-dihydroceramide. J. Biol. Chem. 1993, 268 (35), 26226-26232.
          44. Pushkareva, M.Y.; Bielawska, A.; Menaldino D.; Liotta, D.; Hannun Y.A. Regulation of Sphingosine-Activated Protein Kinases: Specificity of Activation by Sphingoid Bases and Inhibition by Free Fatty Acids. Biochem. J. 1993, 294 (3), 699-703.
          45. Sperka, J.; Liotta, D.C. Onium Ions Are Not On The Reaction Coordinate In The Formation Of Heterocycles Via Electrophile-Induced Alkenol Cyclizations. Heterocycles. 1993, 35 (2), 701-706.
          46. Mathez, D.; Schinazi, R.F.; Liotta, D.C.; Leibowitch, J. Infectious Amplification of Wild Type Human Immunodeficiency Virus from Patients’ Lymphocytes and their Modulation by Reverse Transcriptase Inhibitors In Vitro. Antimicrob. Agents Chemother. 1993, 37 (10), 2206-2211.
          47. Wang, J.; Wurster, J.A.; Wilson, L.J.; Liotta, D. Stereocontrolled Glycosylations Via Additions of Sulfur Electrophiles to Glycals. Tetrahedron Lett. 1993, 34 (31), 4881-4884.
          48. Jones, D.K.; Liotta, D.C. Episulfonium Ions May not be the Stereodeterminants in Glycosylations of 2-Thioalkyl Pyranosides. Tetrahedron Lett. 1993, 34 (45), 7209-7212.
          49. Lagu, B.R.; Crane, H.M.; Liotta, D.C. Highly Diastereoselective Aldol Reactions of Chiral Methyl Ketones. J. Org. Chem. 1993, 58 (16), 4191-4193.
          50. Wilson, J.E.; Martin, J.L.; Borrota-Esoda, K.; Hopkins, S.; Painter, G.; Liotta, D.C.; Furman, P.A. The 5′-Triphosphates of the (-) and (+) Enantiomers of Cis-5-Fluoro-1-[2-(Hydroxymethyl)-1,3-Oxathioane-5-yl]Cytosine Equally Inhibit Human Immunodeficiency Virus Type-1 Reverse Transcriptase. Antimicrob. Agents Chemother. 1993, 37 (8), 1720-1722.
          51. Schinazi, R.F.; Lloyd, R.M.; Nguyen, M.; Cannon, D.L.; McMillan, A.; Ilksoy, N.; Chu, C.K.; Liotta, D.C.; Bazmi, H.J.; Mellors, J.W. Characterization of Human Immunodeficiency Viruses Resistant to Oxathiolane-Cytosine Nucleosides. Antimicrob. Agents Chemother. 1993, 37 (4), 875-881.
          52. Schinazi, R.F.; Goudgaon, N.; Soria, J.; Liotta, D.C. Synthesis, Antiviral Activity, Cytotoxicity and Cellular Pharmacology of 5-Carboranyl-Pyrimidine Nucleosides. Advances in Neutron Capture Therapy. 1993, 285-288.
          53. Van Roey, P.; Pangborn, W.A.; Schinazi, R.F.; Painter, G.; Liotta, D.C. Absolute Configuration of the Antiviral Agent (-)-Cis-5-Fluoro-1-[2-(Hydroxymethyl)-1,3-Oxathioan-5-yl]Cytosine. Antiviral Chem. Chemother. 1993, 4 (6), 369-375.
          54. Shewach, D.S.; Liotta, D.C.; Schinazi, R.F. Affinity of the Antiviral Enantiomers of Oxathiolane Cytosine Nucleosides for Human 2′-Deoxycytidine Kinase. Biochem. Pharmacol. 1993, 45 (7), 1540-1543.
          55. Frick, L.W.; St John, L.; Taylor, L.C.; Painter, G.R.; Furman, P.A.; Liotta, D.C.; Furfine, E.S.; Nelson, D.J. Pharmacokinetics, Oral Bioavailability and Metabolic Disposition in Rats of (-)-cis-5-Fluoro-1-[2-(Hydroxymethyl)-1,3-Oxathiolan-5-yl] Cytosine, a Nucleoside Analog Active Against Human Immunodeficiency Virus and Hepatitis B Virus. Antimicrob. Agents Chemother. 1993, 37 (11), 2285-2292.
          56. Wilson, L.J.; Choi, W.; Spurling, T.; Liotta, D.C.; Schinazi, R.F.; Cannon, D.; Painter, G.R.; St. Clair, M.; Furman, P.A. The Synthesis and Anti-HIV Activity of Pyrimidine Dioxanyl Nucleosides. Bioorg. Med. Chem. Lett. 1993, 3 (2), 169-174.
          57. Choi, W.; Yeola, S.; Liotta, D.C.; Schinazi, R.F.; Painter, G.R.; Davis, M.; St. Clair, M.; Furman, P.A. Synthesis, Anti-Human Immunodeficiency Virus and Anti-Hepatitis B Virus Activity of Pyrimidine Oxathiolane Nucleosides. Bioorg. Med. Chem. Lett. 1993, 3 (4), 693-606.
          58. Jones, D.K.; Liotta, D.C.; Shinkai, I.; Mathre, D.J. Origins of the Enantioselectivity Observed in Oxazaborolidine-Catalyzed Reductions of Ketones. J. Org. Chem. 1993, 58 (4), 799-801.
          59. Hager, M.W.; Liotta, D.C. An Efficient Synthesis of 3′-Fluoro-3′-deoxythymidine (FLT). Tetrahedron Lett. 1992, 33 (47), 7083-7086.
          60. Wurster, J.A.; Wilson, L.J.; Morin, G.T.; Liotta, D. Suppression of Racemization During the Diastereoselective C-3 Functionalization of 5-Hydroxymethyl-2-(5H)-furanones. Tetrahedron Lett. 1992, 33 (39), 5689-5692.
          61. Chang, C.N.; Doong, S.L.; Zhou, J.H.; Beach, J.W.; Jeong, L.S.; Chu, C.K.; Tsai, C.H.; Cheng, Y.C.; Liotta, D.; Schinazi, R. Deoxycytidine deaminase-resistant Stereoisomer is the Active Form of (+/-)-2′,3′-dideoxy-3′-thiacytidine in the Inhibition of Hepatitus B Virus Replication. J. Biol. Chem. 1992, 267 (20), 13938-13942.
          62. Schinazi, R.F.; McMillan, A.; Cannon, D.; Mathis, R.; Lloyd, R.M.; Peck, A.; Sommadossi, J.; St. Clair, M.; Wilson, J.; Furman, P.A.; Painter, G.; Choi, W.; Liotta, D.C. Selective Inhibition of Human Immunodeficiency Viruses by Racemates and Enantiomers of Cis-5-fluoro-1-[2-hydroxymethyl)-1,3-oxythiolan-5-yl] Cytosine. Antimicrob. Agents Chemother. 1992, 36 (11), 2423-2431.
          63. Furman, P.A.; Davis, M.; Liotta, D.C.; Paff, M.; Frick, L.W.; Nelson, D.J.; Dornsife, R.E.; Wurster, J.A.; Wilson, L.J.; Fyfe, J.A.; Tuttle, J.V.; Miller, W.H.; Condreay, L.; Averett, D.R.; Schinazi, R.F.; Painter, G.R. The Anti-Hepatitis B Virus Activities, Cytotoxicities and Anabolic Profiles of the (-) and (+) Enantiomers of Cis-5-fluoro-1-[2-hydroxymethyl)-1,3-Oxythiolan-5-yl]Cytosine . Antimicrob. Agents Chemother. 1992, 36 (12), 2686-2692.
          64. Schinazi, R.F.; Boudinot, F.D.; Ibrahim, S.S.; Manning, C.; McClure, H.M.; Liotta, D.C. Pharmacokinetics and Metabolism of Racemic 2′,3′-Dideoxy-5-Fluoro-3′-Thiacytidine in Rhesus Monkeys. Antimicrob. Agents Chemother. 1992, 36 (11), 2432-2438.
          65. Hoong, L.K.; Strange, L.E.; Liotta, D.C.; Koszalka, G.W.; Burns, C.L.; Schinazi, R.F. Enzyme-Mediated Enantioselective Preparation of Pure Enantiomers of the Antiviral Agent 2’,3’,-dideoxy-5-fluoro-3’-thiacytidine (FTC) and Related Compounds. J. Org. Chem. 1992, 57 (21), 5563-5565.
          66. Durkin, K.; Liotta, D.; Rancourt, J.; Lavallée, J.F.; Boisvert, L.; Guindon, Y. Stereoselective Hydrogen-Transfer Reactions Involving Acyclic Radicals. A Study of Radical conformations Using Semiempirical Calculations. J. Am. Chem. Soc. 1992, 114 (12), 4912-4914.
          67. Wilson, L.J.; Liotta, D.C. Diastereoselective Sulfenylation Reactions Employing N-Phenylthiolactams Under Nonbasic Conditions. J. Org. Chem. 1992, 57 (7), 1948-1950.
          68. Enkvetchakul, B.; Barnett, T.; Liotta, D.C.; Geisler, V.; Menaldino, D.; Merrill, A.H.; Birt, D.F. Influences of Sphingosine on Two-Stage Skin Tumorigenesis in Sencar Mice. Cancer Lett. 1992, 62 (1), 35-42.
          69. Schinazi, R.F.; Chu, C.K.; Peck, A.; McMillan, A.; Mathis, R.; Cannon, D.; Jeong, L.S.; Beach, J.; Choi, W.; Yeola, S.; Liotta, D.C. Activity of Four Optical Isomers of 2′,3′-Dideoxy-3′-Thiacytidine (BCH-189) Against Human Immunodeficiency Virus Type 1 in Human Lymphocytes. Antimicrob. Agents Chemother. 1992, 36 (3), 672-676.
          70. Swiss, K.A.; Hinkley, W.; Maryanoff, C.A.; Liotta, D.C. Complementary Facial Selectivity in Conjugate Additions to g-Hydroxyenones. Synthesis. 1992, (1-2), 127-131.
          71. Doong, S.L.; Tsai, C.H.; Schinazi, R.F.; Liotta, D.C.; Cheng, Y.C. Inhibition of the Replication of Hepatitis B Virus In Vitro by 2′,3′-Dideoxy-3′-Thiacytidine and Related Analogues. Proc. Natl. Acad. Sci. U.S.A. 1991, 88 (19), 8495-8499.
          72. Choi, W.B.; Wilson, L.J.; Yeola, S.; Liotta, D.C.; Schinazi, R.F. In Situ Complexation Directs the Stereochemistry of N-Glycosylation in the Synthesis of Thialanyl and Dioxolanyl Nucleoside Analogs. J. Am. Chem. Soc. 1991, 113 (24), 9377-9379.
          73. Swiss, K.A.; Choi, W.B.; Liotta, D.C.; Abdel-Magid, A.F.; Maryanoff, C.A. Use of Magnesium Cation in Aldol Additions – A Convenient Method for Achieving Anti-Aldol Selectivity. J. Org. Chem. 1991, 56 (21), 5978-5980.
          74. Merrill, A.H.; Liotta, D.C. Lipids as Hormones and Second Messengers. Curr. Opin. Struct. Biol. 1991, 1 (4), 516-521.
          75. Hager, M.W.; Liotta, D.C. Cyclization Protocols for Controlling the Glycosidic Stereochemistry of Nucleosides. Application to the Synthesis of the Antiviral Agent, 3′-azido-3’-deoxythymidine (AZT). J. Am. Chem. Soc. 1991, 113 (13), 5117-5119.
          76. Goldkorn, T.; Dressler, K.A.; Muindi, J.; Radin, N.S.; Mendelsohn, J.; Menaldino, D.; Liotta, D.; Kolesnick, R.N. Ceramide Stimulates Epidermal Growth Factor Receptor Phosphorylation in A431 Human Epidermoid Carcinoma Cells: Evidence that Ceramide May Mediate Sphingosine Action. J. Biol. Chem. 1991, 266 (24), 16092-16097.
          77. Liotta, D.; Swiss, K. Addition Reactions with Formation of Carbon-Sulfur or Carbon Selenium Bonds. Comprehensive Organic Chemistry (B. M. Trost, I. Fleming, Ed., S. V. Ley, Vol. Ed.) Pergamon Press. 1991, 7, 515-526.
          78. Stevens, V.L.; Nimkar, S.; Jamison, W.C.L.; Liotta, D.C.; Merrill, A.H. Characteristics of the Growth Inhibition and Cytotoxicity of Long-chain (Sphingoid) Bases for Chinese Hamster Ovary Cells: Evidence for an Involvement of Protein Kinase C. Biochim. Biophys. Acta. 1990, 1051 (1), 37-45.
          79. Liebeskind, L.S.; Chidambaram, R.; Nimkar, S.; Liotta, D. A Synthesis of the Abietane Diterpenoid Quinone (±) Royleanone via Maleoylcobalt Technology. Tetrahedron Lett. 1990, 31 (26), 3723-3726.
          80. Durkin, K.A.; Liotta, D. Solvation Controlled Diastereofacial Selectivity in Alkylations of Bicyclic Lactam Enolates. J. Am. Chem. Soc. 1990, 112 (22), 8162-8163.
          81. Swiss, K.A.; Liotta, D.C.; Maryanoff, C.A. Mechanistic Aspects of Ligand-Assisted Nucleophilic Addition Reactions. J. Am. Chem. Soc. 1990, 112 (25), 9393-9394.
          82. Durkin, K.; Sherrod, M.; Liotta, D. Empirical Derivation of Molecular Mechanics Parameter Sets: Application to b-Lactams. Adv. Modeling. 1990, JAI Press, 2, 93-133.
          83. Wilson, L.J.; Liotta, D. A General Method for Controlling Glycosylation Stereochemistry in the Synthesis of 2′-Deoxyribose Nucleosides. Tetrahedron Lett. 1990, 31 (13), 1815-1818.
          84. Swiss, K.; Choi, W.B.; Mohan, J.; Barnum, C.; Saindane, M.; Zima, G.; Liotta, D. Reactions Involving Selenium Metal As An Electrophile. Scope and Limitations of the Enolate-Selenolate Transformation. Heteroatom Chem. 1990, 1 (2), 141-149.
          85. Greenberg, P.; Merrill, A.H.; Liotta, D.C.; Grabowski, G.A. Human acid β-Glucosidase: Use of Sphingosyl and N-Alkyl-Glucosylamine Inhibitors to Investigate the Properties of the Active Site. Biochim. Biophys. Acta. 1990, 1039 (1), 12-20.
          86. Durkin, K.A.; Sherrod, M.J.; Liotta, D. A New MODEL Parameter Set for β-Lactams. J. Org. Chem. 1989, 54 (25), 5839-5841.
          87. Slife, C.W.; Wang, E.; Hunter, R.; Wang, S.; Burgess, C.; Liotta, D.C.; Merrill, A.H. Free Sphingosine Formation from Endogenous Substrates by a Liver Plasma Membrane System with a Divalent Cation Dependence and a Neutral pH Optimum. J. Biol. Chem. 1989, 264 (18), 10371-10377.
          88. Rodriguez-Paris, J.; Shoji, M.; Yeola, S.; Liotta, D.; Vogler, W.R.; Kuo, J.F. Fluorimetric Studies of Protein Kinase C Interactions with Phospholipids. Biochem. Biophys. Res. Commun. 1989, 159 (2), 495-500.
          89. McCormick, M.; Monahan, R.; Soria, J.; Goldsmith, D.; Liotta, D. Effects of Substitution on Intramolecular Alkoxypalladation Carbonylation Reactions. J. Org. Chem. 1989, 54 (19), 4485-4487.
          90. Merrill Jr., A.H.; Nimkar, S.; Menaldino, D.; Hannun, Y.A.; Loomis, C.; Bell, R.M.; Tyagi, S.R.; Lambeth, J.D.; Stevens, V.L.; Hunter, R.; Liotta, D.C. Structural Requirements for Long-Chain (Sphingoid) Base Inhibition of Protein Kinase C in vitro and for the Cellular Effects of These Compounds. Biochemistry. 1989, 28 (8), 3138-3145.
          91. Wilson, E.; Wang, E.; Mullins, R.E.; Uhlinger, D.J.; Liotta, D.C.; Lambeth, J.D.; Merrill, A.H. Modulation of the Free Sphingosine Levels in Human Neutrophils by Phorbol Esters and Other Factors. J. Biol. Chem. 1988, 263 (19), 9304-9309.
          92. Solomon, M.; Hoekstra, W.; Zima, G.; Liotta, D. The Case Favoring Direct C-Alkylation of Heteroatom-Substituted Enolates. J. Org. Chem. 1988, 53 (21), 5058-5062.
          93. Solomon, M.; Jamison, W.C.L.; McCormick, M.; Liotta, D.; Cherry, D.A.; Mills, J.E.; Shah, R.D.; Rodgers, J.D.; Maryanoff, C.A. Ligand-Assisted Nucleophilic Additions. Control of Site and Face Attack of Nucleophiles on 4-Oxido Enones. J. Am. Chem. Soc. 1988, 110 (11), 3702-3704.
          94. Nimkar, S.; Menaldino, D.; Merrill, A.H.; Liotta, D. A Stereoselective Synthesis of Sphingosine, A Protein Kinase C Inhibitor. Tetrahedron Lett. 1988, 29 (25), 3037-3040.
          95. Dunams, T.; Hoekstra, W.; Pentaleri, M.; Liotta, D. Molecular Aggregation and Its Applicability to Synthesis. The Diels-Alder Reaction. Tetrahedron Lett. 1988, 29 (31), 3745-3748.
          96. Liotta, D.; Saindane, M.; Waykole, L.; Stephens, J.; Grossman, J. Trajectories of Proton Transfer Reactions. Experimental Determination of the Magnitude of Primary Deuterium Isotope Effects for Proton-Transfers Occurring at Acute Angles. J. Am. Chem. Soc. 1988, 110 (8), 2667-2668.
          97. Merrill, A.H.; Wang, E.; Mullins, R.E.; Jamison, W.C.L.; Nimkar, S.; Liotta, D.C. Quantitation of Free Sphingosine in Liver by High-Performance Liquid Chromatography. Anal. Biochem. 1988, 171 (2), 373-381.
          98. Kaufman, M.; Jamison, W.C.L.; Liotta, D. Reaction of Coal with 1,2,3,4-Tetrahydroquinoline in a Perflluorocarbon Medium. Fuel. 1987, 66 (12), 1621-1625.
          99. Liotta, D.; Brown, D.; Hoekstra, W.; Monahan, R. Pyridinium Dichromate-Induced 1,3-Oxidative Rearrangements of Enynols. Tetrahedron Lett. 1987, 28 (10), 1069-1072.
          100. Maryanoff, B.E.; Nortey, S.O.; Inners, R.R.; Campbell, S.A.; Reitz, A. B.; Liotta, D.C. Synthesis of C-Arabinofuranosides. Phosphonate and Carboxylate Isosteres of D-Arabinose-1,5-Diphosphate. Carbohydr. Res. 1987, 171 (1), 259-278.
          101. Reitz, A.B.; Nortey, S.O.; Maryanoff, B.E.; Liotta, D.; Monahan, R. Stereoselectivity of Electrophile-Promoted Cyclizations of g-Hydroxyalkenes. An Investigation of Carbohydrate-Derived and Model Substrates. J. Org. Chem. 1987, 52 (19), 4191-4204.
          102. Liotta, D.; Ott, W. Triene Cyclizations. Total Synthesis of Pallescensin A. Synth. Commun. 1987, 17 (14), 1655-1665.
          103. Liotta, D.; Monahan, R.; Waykole, L.; Brown, D. Nucleophilic Selenium. Organoselenium Chemistry. 1987, 207-242. (Wiley-Interscience. Eds.).
          104. Liotta, D.; Saindane, M.; Monahan, R.; Brothers, D.; Fivush, A. Rearrangement of α- PhenylselenenylKetones. Synth. Commun. 1986, 16 (12), 1461-1468.
          105. Liotta, D.; Monahan, R. Selenium in Organic Synthesis. Science. 1986, 231 (4736), 356-361.
          106. Kaufman, M.; Jamison, W.C.L.; Liotta, D. Coal Liquefaction in a Fluorocarbon. 1. Nitrogen Compounds as Hydrogen Transfer Agents. Fuel. 1986, 65 (1), 148-150.
          107. Fraser-Reid, B.; Underwood, R.; Osterhout, M.; Grossman, J.; Liotta, D. Some Observations on the Relative Reactivities of a-Enones of Oxanes and Cyclohexanes. J. Org. Chem. 1986, 51 (11), 2152-2155.
          108. Liotta, D.; Saindane, M.; Barnum, C.; Zima, G. Synthetic Applications of 2- Phenylselenenylenones-III: An Overview. Tetrahedron. 1985, 41 (21), 4881-4889.
          109. Goldsmith, D.J.; Liotta, D.C.; Volmer, M.; Hoekstra, W.; Waykole, L. Preparation and Reactivity of α-Phenylselenyl Ethers. Tetrahedron 1985, 41 (21), 4873-4880.
          110. Gupton, J.T.; Hertel, G.; DeCrescenzo, G.; Colon, C.; Baran, D.; Dukesherer, D.; Novick, S.; Liotta, D.; Idoux, J.P. Regioselective fluoroalkoxylation and polyfluoroalkoxylation of aromatic and heteroaromatic polyhalides. Can. J. Chem. 1985, 63 (11), 3037-3042.
          111. Bresciani-Pahor, N.; Calligaris, M.; Randaccio, L.; Marzilli, L.G.; Summers, M.F.; Toscano, P.J.; Grossman, J.; Liotta, D. The 2,2,2-Trifluoroethyl Ligand: A Structural “Reporter” Group for its Carbanion Character in Organometallic Compounds. Organometallics. 1985, 4 (4), 630-636.
          112. Liotta, D.; Saindane, M.; Sunay, U.; Jamison, W.C.L.; Grossman, J.; Phillips, P. Acetylide Additions to Enediones. Regioselectivity Based on Stereoelectronic Control. J. Org. Chem. 1985, 50 (17), 3241-3243.
          113. Liotta, D. New Organoselenium Methodology. Acc. Chem. Res. 1984, 17 (1), 28-34.
          114. Liotta, D. The Chemistry of 2-Phenylselenenylenones. Proceedings of the Fourth International Conference on the Organic Chemistry of Selenium and Tellurium. 1983, 278-96.
          115. Goldsmith, D.; Liotta, D.; Saindane, M.; Waykole, L.; Bowen, P. 3-Alkylfurans as Useful Synthetic Equivalents for Substituted d2-Butenolides. Tetrahedron Lett. 1983, 24 (52), 5835-5838.
          116. Liotta, D.; Arbiser, J.; Short, J.W.; Saindane, M. Simple, Inexpensive Procedure for the Large Scale Production of Alkyl Quinones. J. Org. Chem. 1983, 48 (17), 2932-2933.
          117. Liotta, D.; Saindane, M.; Waykole, L. New Probes for Electron-Transfer Processes. Evidence Supporting the Single-Electron-Transfer Mechanism in Additions of Carbanions to Dienones. J. Am. Chem. Soc. 1983, 105 (9), 2922-2923.
          118. Liotta, D.; Saindane, M.; Ott, W. A Simple, Efficient Synthesis of 3-Substituted Furans. Tetrahedron Lett. 1983, 24 (24), 2473-2476.
          119. Menger, F.M.; Grossman, J.; Liotta, D.C. Transition State Pliability in Nitrogen-to-Nitrogen Proton Transfer. J. Org. Chem. 1983, 48 (6), 905-907.
          120. Lehman, T.A.; Bursey, M.M.; Harvan, D.J.; Hass, J.R.; Liotta, D.; Waykole, L. Comparison of Collisional Activation Spectra of Some Positive Ions Produced Both by Charge Reversal of Negative Ions and by Decomposition of Positive Ions. Org. Mass. Spec. 1982, 17 (12), 607-611.
          121. Liotta, D.; Sunay, U.; Ginsberg, S. Phosphonosilylations of Cyclic Enones. J. Org. Chem. 1982, 47 (11), 2227-2229.
          122. Liotta, D.; Saindane, M.; Brothers, D. Base-induced Rearrangements of a-Phenylselenenyl Ketones. J. Org. Chem. 1982, 47 (8), 1598-1600.
          123. Liotta, D.; Zima, G.; Saindane, M. Origins of Regio- and Stereoselectivity in Additions of Phenylselenenyl Chloride to Allylic Alcohols and the Applicability of These Additions to a Simple 1,3-Enone Transposition Sequence. J. Org. Chem. 1982, 47 (7), 1258-1267.
          124. Baker, A.D.; Horozoglu Armen, G.; Guang-Di, Y.; Liotta, D.; Flannagan, N.; Barnum, C.; Saindane, M.; Zima, G.C.; Grossman, J. Photoelectron Spectra of Alkyl Aryl Selenides. Electronic and Steric Factors in the Observation of Rotamers. J. Org. Chem. 1981, 46 (21), 4127-4130.
          125. Liotta, D.; Barnum, C.S.; Saindane, M. Synthetic Applications of 2-Phenylselenenylenones. 2. Synthesis of Dihydrojasmone and cis-Jasmone. J. Org. Chem. 1981, 46 (21), 4301-4304.
          126. Liotta, D.; Saindane, M.; Barnum, C.; Ensley, H.; Balakrishan, P. Reactions Involving Selenium Metal as an Electrophile. 2. A General Procedure for the Preparation of Unsaturated β- Dicarbonyl Compounds. Tetrahedron Lett. 1981, 22 (32), 3043-3046.
          127. Liotta, D.; Saindane, M.; Barnum, C. Selective Reactions of Carbanions with p-Quinones. The Aggregate Model. J. Org. Chem. 1981, 46 (16), 3369-3370.
          128. Liotta, D.; Sunay, U.; Santiesteban, H.; Markiewicz, W. Phenyl Selenide Anion, A Superior Reagent for SN2 Cleavage of Esters and Lactones. J. Org. Chem. 1981, 46 (13), 2605-2610.
          129. Liotta, D.; Barnum, C.; Puleo, R.; Zima, G.; Bayer, C.; Kezar, H.S. A Simple Method for the Efficient Synthesis of Unsaturated β-Dicarbonyl Compounds. J. Org. Chem. 1981, 46 (14), 2920-2923.
          130. Liotta, D.; Saindane, M.; Barnum, C. Diels-Alder Reactions Involving Cross-Conjugated Dienones. Effects of Substitution on Reactivity. J. Am. Chem. Soc. 1981, 103 (11), 3224-3226.
          131. Baker, A.D.; Brisk, M.A.; Liotta, D.C. Electron Spectroscopy: Ultraviolet and X-Ray Excitation. Anal. Chem. 1980, 52 (5), 161R-174R.
          132. Liotta, D.; Zima, G.; Barnum, C.; Saindane, M. Reactions Involving Selenium Metal as an Electrophile. The Enolate-Selenolate Transformation. Tetrahedron Lett. 1980, 21 (38), 3643-3646.
          133. Zima, G.; Barnum, C.; Liotta, D. Synthetic Applications of 2-Phenylselenenyl Enones. Selective Formation of Exocyclic or Endocyclic Enones from a Common Intermediate. J. Org. Chem. 1980, 45 (13), 2736-2737.
          134. Liotta, D.; Zima, G. Synthetic Applications of Phenylselenenyl Chloride Additions. A Simple 1,3-Enone Transposition Sequence. J. Org. Chem. 1980, 45 (12), 2551-2553.
          135. Goldsmith, D.; Liotta, D.; Lee, C.; Zima, G. The Reactions of β,γ-Unsaturated Acids with Phenylselenenyl Chloride. Decarboxylative Elimination vs. Phenylselenolactonization. Tetrahedron Lett. 1979, 20 (50), 4801-4804.
          136. Zima, G.; Liotta, D. A General Synthesis of 2-Phenylselenenylenones. The Reaction of Unsaturated Ketones with a Phenylselenenyl Chloride/Pyridine Complex. Synth. Commun. 1979, 9 (8), 697-703.
          137. Liotta, D.; Paty, P.B.; Johnson, J.; Zima, G. Synthetic Applications of Phenyltrimethylsilylselenide. Tetrahedron Lett. 1978, 19 (51), 5091-5094.
          138. Liotta, D.; Zima, G. An Examination of the Synthetic Utility of Phenylselenenyl Chloride Additions to Olefins. Tetrahedron Lett. 1978, 19 (50), 4977-4980.
          139. Baker, A.D.; Wong, D.; Lo, S.; Bloch, M.; Horozoglu, G.; Goldman, N.L.; Engel, R.; Liotta, D.C. The Reaction N-Aryl Nitrones with Dichloroketene: A New Synthesis of Isatins. Tetrahedron Lett. 1978, 19 (3), 219-222.
          140. Baker, A.D.; Brisk, M.A.; Liotta, D.C. Electron Spectroscopy: Ultraviolet and X-Ray Excitation. Anal. Chem. 1978, 50 (5), 328R-346R.
          141. Liotta, D.; Markiewicz, W.; Santiesteban, H. The Generation of Uncomplexed Phenyl Selenide Anion and Its Applicability of SN2-Type Cleavages. Tetrahedron Lett. 1977, 18 (50), 4365-4368.
          142. Liotta, D.; Santiesteban, H. Nucleophilic Ring Opening of Lactones via SN2-Type Reactions with Uncomplexed Phenyl Selenide Anion. Tetrahedron Lett. 1977, 18 (50), 4369-4372.
          143. Paquette, L.A.; Liotta, D.C.; Liao, C.C.; Wallis, G.T.; Eickman, N.; Clardy, J.; Gleiter, R. Endoperoxidation of Conformationally Fixed Norcaradienes by Singlet Oxygen. Frontier Molecular Orbital Basis for the Operability of 1O2 Quenching by Hydrazides. J. Am. Chem. Soc. 1976, 98 (20), 6413-6416.
          144. Paquette, L.A.; Liao, C.C.; Liotta, D.C.; Fristad, W.E. Reversal of Stereospecificity During Allylic Hydroperoxidation of 3-Norcarene and Bicyclo [4.2.0]Oct-3-ene Derivatives Arising from Structurally Enforced Quenching of Singlet Oxygen by the Hydrazide Functionality. J. Am. Chem. Soc. 1976, 98 (20), 6412-6413.
          145. Paquette, L.A.; Liotta, D.C; Baker, A.D. Frontier Molecular Orbital Basis for the Structurally Dependent Regiospecific Reactions of Singlet Oxygen with Polyolefins. Tetrahedron Lett. 1976, 17 (31), 2681-2684.
          146. Baker, A.D; Brisk, M.A.; Venanzi, T.J.; Kwon, Y.S.; Sadka, S.; Liotta, D.C. Spiroconjugation Involving Sulfur 3p Atomic Orbitals. Tetrahedron Lett. 1976, 17 (38), 3415-3418.
          147. Baker, A.D.; Brisk, M.A.; Liotta, D.C. Electron Spectroscopy-Ultraviolet Excitation. Anal. Chem. 1976, 48 (5), 281R-294R.
          148. Liotta, D.; Engel, R. The Thermal Decomposition of Alkoxycarbonyl Thiocyanates and Isothiocyanates. Can. J. Chem. 1975, 53 (6), 907-912.
          149. Liotta, D.; Baker, A.D.; Goldman, N.L.; Engel, R. Reactions of N-Aryl Nitrogen Oxides. 2. The Reaction of N-Aryl Nitrones with Oxalyl Chloride. J. Org. Chem. 1974, 39 (13), 1975-1976.
          150. Liotta, D.; Baker, A.D.; Goldstein, S.; Goldman, N.L.; Weinstein-Lanse, F.; Felsen-Reingold, D.; Engel, R. Reactions of N-Aryl Nitrogen Oxides. 1. Selective Ortho-Chlorination in the Reactions of Aryl Nitrones and Amine Oxides with Thionyl Chloride or Phosgene. J. Org. Chem. 1974, 39 (18), 2718-2722.
          151. Liotta, D.; Baker, A.D.; Weinstein, F.; Felsen, D.; Engel, R.; Goldman, N.L. The Reaction of N-Aryl Nitrones with Thionyl Chloride or Phosgene. J. Org. Chem. 1973, 38 (19), 3445-3446.
          152. Engel, R.; Santo, T.; Liotta, D.; Freed, D. Enhanced Nucleophilic Displacement in Phosphinite Esters. J. Chem. Soc. D. Chem. Commun. 1970, 646a.
          153. Engel, R.R.; Liotta, D. Thermal Decomposition of Phosphorothioates. J. Chem. Soc. C. 1970, 523-524.